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Computational analysis of human plasma N-glycome and genotypes
Computational analysis of human plasma N-glycome and genotypes
Ana Sofia Pedrosa Pinto
Glycosylation is one of the most extensive protein modifications. Glycans influence both structure and function of the proteins and known to have important roles in physiological and pathological processes. The absence of a universal code for glycan synthesis combined with the technological challenges faced by glycan quantification analysis has hindered the knowledge about the processes regulating the assembly of glycans. Major breakthroughs in analytical procedures created the...
Design and testing of Adepantins - functional artificial antibiotics
Design and testing of Adepantins - functional artificial antibiotics
Nada Ilić
As an important part of the innate immune system of all organisms, antimicrobial peptides, are considered as a possible solution for fighting bacteria resistant to standard antibiotics.Crucial characteristic of peptide antibiotic, as drug candidate is its high selectivity, parameterized as the ratio of concentration causing 50% haemolysis (HC50) against erythrocytes and the minimal inhibitory concentration (MIC) against the reference bacterium Escherichia coli. Using the “Designer”...
Elementi kontekstualnog pristupa učenju i poučavanju kao čimbenici uspješnosti nastave Tehničke kulture
Elementi kontekstualnog pristupa učenju i poučavanju kao čimbenici uspješnosti nastave Tehničke kulture
Damir Purković
Zbog iskustvene i aplikativne prirode tehničkog odgoja i obrazovanja kakvoća nastavnog konteksta može presudno utjecati na ostvarivanje ciljeva nastave. U radu se stoga iznose relevantni teorijski i empirijski dosezi koji potkrepljuju značaj konteksta i kontekstualnog pristupa nastavi za razvoj učenika. Uviđajući problem optimizacije nastavnog konteksta u nastavi Tehničke kulture, provedeno je istraživanje s ciljem utvrđivanja važnosti izdvojenih kontekstualnih elemenata i...
Identification, redesign and characterization of anuran antimicrobial peptides
Identification, redesign and characterization of anuran antimicrobial peptides
Tomislav Rončević
Antimicrobial peptides (AMPs) are structurally diverse molecules naturally produced by most organisms, with direct antimicrobial activity against pathogens and often showing other immune-related properties. Anurans are a particularly rich source of these peptides, with ~2000 different sequences reported in Database of Anuran Defense Peptides (DADP). A novel approach for simultaneous multispecies peptide identification has been developed by exploiting the highly conserved signal peptide...
Izbor reprezentativnog skupa membranskih proteina poznate strukture: razvoj poboljšanih algoritama uporabom koncepta nasumičnog modela
Izbor reprezentativnog skupa membranskih proteina poznate strukture: razvoj poboljšanih algoritama uporabom koncepta nasumičnog modela
Jadranko Batista
Strukturu membranskih proteina osjetno je teže eksperimentalno odrediti nego strukturu topljivih proteina. Kako bi se razvio pouzdani model za predviđanje strukture proteina, potrebno je provesti njegovu optimizaciju na što većem (reprezentativnom) skupu membranskih proteina poznatih struktura, međusobnih sličnosti ispod 30%. Postojeći algoritmi za izbor reprezentativnih skupova integralnih membranskih proteina alfa vrste ne koriste informaciju o složenosti strukture, iako se...
Metodičko znanje o kemijskim vezama s naglaskom na jezična pitanja u Republici Hrvatskoj
Metodičko znanje o kemijskim vezama s naglaskom na jezična pitanja u Republici Hrvatskoj
Roko Vladušić
Prepoznajući važnost, ali i problematičnost razumijevanja modela kovalentnog i ionskog vezivanja, osmišljeno je i provedeno istraživanje o poteškoćama i nastavnim rješenjima za osnaživanje metodičkog znanja (MZ) o kemijskom vezivanju. Postavljena su tri cilja: (a) utvrditi studentsko razumijevanje određenih riječi i simbola koje se koristi u nastavi kemije te pratiti osviještenost budućih nastavnika o pozornosti koju treba pridati jeziku nastave kemije; (b) istražiti...
Microheterogeneity in Ethanol-Water Mixture
Microheterogeneity in Ethanol-Water Mixture
Marijana Mijaković
Ethanol­-water liquid mixture was analyzed by the method of Molecular Dynamics, over the whole composition range to elucidate its micro structure. A recently introduced concept of microheterogeneity was used to describe mixture's behaviour. It was discovered that there are at least three structural regimes with respect to composition range in aqueous ethanol at ambient conditions. Up to approximately 0.15 mole fraction of ethanol, hydrophobic ethanol's sites distribution declines from...
On the nature of structural fluctuations in complex liquids
On the nature of structural fluctuations in complex liquids
Martina Požar
The analysis of different types of structuring, present in simple and complex liquids and their mixtures, was done using the method of molecular dynamics. Complex mixtures have at least one associative component, such as water, alcohols (mono-ols and diols) and amines. The supra-molecular structuring in these mixtures is detected, described, quantified and connected with the atom-atom interactions is the molecules. These systems have interesting fluctuation behaviors, as shown through...
Optical properties of noble metal nanocluster hybrids and their potential for biosensing
Optical properties of noble metal nanocluster hybrids and their potential for biosensing
Željka Sanader Maršić
Linear and nonlinear optical properties of functionalized forms of noble metal nanoclusters are addressed in this thesis. Noble metal nanoclusters belong to nonscalable regime in which each atom counts. They exhibit molecular like electronic transitions, due to quantum confinement effects, which are strongly influenced by structure. These systems have potential for applications in biosensing and bioimaging, based on their unique optical, electronic and structural properties, after being...
Poučavanje početnog programiranja oblikovanjem računalnih igara
Poučavanje početnog programiranja oblikovanjem računalnih igara
Monika Mladenović
Programiranje je apstraktno i teško, pogotovo za početnike na osnovnoškolskoj razini školovanja. Za „klasično“ poučavanje programiranja uglavnom se koriste tekstualni programski jezici, što dodatno otežava učenje početnicima zbog naglašenih problema sintakse. Osim toga, dodatni problem je kontekst programiranja koji se uglavnom svodi na rješavanje matematičkih problema, što pripadnicima digitalnog doba smanjuje motivaciju. Ublažavanje problema sintakse, ali i pomak...
Role of metallic nanoclusters in catalysis for fuel cell feed gas purification and hydrogen storage
Role of metallic nanoclusters in catalysis for fuel cell feed gas purification and hydrogen storage
Marjan Krstić
Catalyticreactivity of the small transition and coinage metal nanoclusters have been theoretically studied in context of (1) advancing fuel cell technology by developing cost-effective techniques to improve quality of the feed gas as well as (2) safe storage and release of hydrogen in its gaseous state at room temperatures and pressures. In order to address the challenge concerning the improvement the quality of fuel cell feed gas reactions of small ruthenium cationic nanoclusters with CO...
Statistical and thermodynamical analysis of the micro-structure in molecular emulsions
Statistical and thermodynamical analysis of the micro-structure in molecular emulsions
Bernarda Kežić-Lovrinčević
Les mélanges aqueux diffèrent des mélanges de liquides simples, du fait que les molécules d'eau tendent à s'associer préférentiellement entre elles au travers de la liaison hydrogène, de ce fait ségréguant les molécules de soluté sans pour autant entraîner une démixtion totale des mélanges. Même des mélanges aussi simples que l'eau et le méthanol exhibent ce type d'ordre. La micro-hétérogénéité (MH) résultante apparaît comme étant distincte des fluctuations de...

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