Paginacija
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Computational analysis of human plasma N-glycome and genotypes
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Ana Sofia Pedrosa Pinto Glycosylation is one of the most extensive protein modifications. Glycans influence both structure and function of the proteins and known to have important roles in physiological and pathological processes. The absence of a universal code for glycan synthesis combined with the technological challenges faced by glycan quantification analysis has hindered the knowledge about the processes regulating the assembly of glycans. Major breakthroughs in analytical procedures created the...
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Design and testing of Adepantins - functional artificial antibiotics
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Nada Ilić As an important part of the innate immune system of all organisms, antimicrobial peptides, are considered as a possible solution for fighting bacteria resistant to standard antibiotics.Crucial characteristic of peptide antibiotic, as drug candidate is its high selectivity, parameterized as the ratio of concentration causing 50% haemolysis (HC50) against erythrocytes and the minimal inhibitory concentration (MIC) against the reference bacterium Escherichia coli. Using the “Designer”...
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Design of novel nanostructured biosensing materials and their application in medical diagnostics
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Hussein Fakhouri This doctoral thesis is focused on the rational design of novel nanostructured biosensing materials and their application in medical diagnostics, in the field of biological aging. Aging and age-related diseases are the consequences of the accumulation of oxidative damage to proteins. One way to measure protein oxidation is to determine levels of protein carbonyls. Currently, protein carbonylation is detected and quantified with 2D gel-based methods using specific fluorescent dyes...
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Elementi kontekstualnog pristupa učenju i poučavanju kao čimbenici uspješnosti nastave Tehničke kulture
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Damir Purković Zbog iskustvene i aplikativne prirode tehničkog odgoja i obrazovanja kakvoća nastavnog konteksta može presudno utjecati na ostvarivanje ciljeva nastave. U radu se stoga iznose relevantni teorijski i empirijski dosezi koji potkrepljuju značaj konteksta i kontekstualnog pristupa nastavi za razvoj učenika. Uviđajući problem optimizacije nastavnog konteksta u nastavi Tehničke kulture, provedeno je istraživanje s ciljem utvrđivanja važnosti izdvojenih kontekstualnih elemenata i...
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Identification, redesign and characterization of anuran antimicrobial peptides
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Tomislav Rončević Antimicrobial peptides (AMPs) are structurally diverse molecules naturally produced by most organisms, with direct antimicrobial activity against pathogens and often showing other immune-related properties. Anurans are a particularly rich source of these peptides, with ~2000 different sequences reported in Database of Anuran Defense Peptides (DADP). A novel approach for simultaneous multispecies peptide identification has been developed by exploiting the highly conserved signal peptide...
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Implementacija strategije predučenja u srednjoškolskoj nastavi kemije
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Snježana Smerdel Strategija predučenja uključuje aktivnosti usmjerene na pripremu učenika za nastavu. Cilj ovog doktorskog rada bio je istražiti primjenu materijala za predučenje u srednjoškolskoj nastavi kemije kako bi se utvrdio učinkovit način njihove izrade kao i implementacije u stvarne nastavne situacije. Svrha prvog dijela rada bila je ispitati situaciju u srednjim školama s obzirom na učestalost primjene različitih aktivnosti predučenja u nastavi kemije te u isto vrijeme istražiti ...
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Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans
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Marina Musa Aging is a process almost all known organisms undergo and it is accompanied by a general loss of function of all important physiological processes, including reduced resistance to cellular stress. While different stresses such as heat or oxidative stress are generally detrimental to the cell and the organism, if they are short and mild enough, they can benefit the organism and confer increased stress resistance later in life and prolong lifespan. This phenomenon is known as hormesis. By...
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Metodičko znanje o kemijskim vezama s naglaskom na jezična pitanja u Republici Hrvatskoj
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Roko Vladušić Prepoznajući važnost, ali i problematičnost razumijevanja modela kovalentnog i ionskog vezivanja, osmišljeno je i provedeno istraživanje o poteškoćama i nastavnim rješenjima za osnaživanje metodičkog znanja (MZ) o kemijskom vezivanju. Postavljena su tri cilja: (a) utvrditi studentsko razumijevanje određenih riječi i simbola koje se koristi u nastavi kemije te pratiti osviještenost budućih nastavnika o pozornosti koju treba pridati jeziku nastave kemije; (b) istražiti...
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Microheterogeneity in Ethanol-Water Mixture
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Marijana Mijaković Ethanol-water liquid mixture was analyzed by the method of Molecular Dynamics, over the whole composition range to elucidate its micro structure. A recently introduced concept of microheterogeneity was used to describe mixture's behaviour. It was discovered that there are at least three structural regimes with respect to composition range in aqueous ethanol at ambient conditions. Up to approximately 0.15 mole fraction of ethanol, hydrophobic ethanol's sites distribution declines from...
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