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undergraduate thesis
Azaspiracidi - toksičnost, mehanizam djelovanja i detekcija
2024. urn:nbn:hr:166:721708
Novak, Dujam
University of Split
Faculty of Science

Cite this document

Novak, D. (2024). Azaspiracidi - toksičnost, mehanizam djelovanja i detekcija (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:721708

Novak, Dujam. "Azaspiracidi - toksičnost, mehanizam djelovanja i detekcija." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:721708

Novak, Dujam. "Azaspiracidi - toksičnost, mehanizam djelovanja i detekcija." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:721708

Novak, D. (2024). 'Azaspiracidi - toksičnost, mehanizam djelovanja i detekcija', Undergraduate thesis, University of Split, Faculty of Science, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:166:721708

Novak D. Azaspiracidi - toksičnost, mehanizam djelovanja i detekcija [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2024 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:166:721708

D. Novak, "Azaspiracidi - toksičnost, mehanizam djelovanja i detekcija", Undergraduate thesis, University of Split, Faculty of Science, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:166:721708

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Metadata
TitleAzaspiracidi - toksičnost, mehanizam djelovanja i detekcija
Title (english)Azaspiracids - toxicity, mechanism and detection
AuthorDujam Novak
MentorStjepan Orhanović (mentor)
Committee memberStjepan Orhanović (predsjednik povjerenstva)
Committee memberAndrea Paut (član povjerenstva)
Committee memberMartina Gudelj (član povjerenstva)
GranterUniversity of Split
Faculty of Science
Split
Defense date and country2024-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Azaspiracidi su vrsta polieterskih toksina koji su prvobitno otkriveni u trovanju koje se dogodilo 1995.-e u Irskoj gdje je nekolicina ljudi pretrpjela simptome trovanja nakon konzumacije dagnji Mytilus edulis. Ime su dobili po svojim kemijskim karakteristikama, imaju cikličku amino skupinu (AZA skupina), tri spiro skupine (-SPIR-) i skupinu karboksilne kiseline (-ACID). Od 1995.-te pa sve do danas, prijavljena su mnoga trovanja azaspiracida konzumacijom školjkaša diljem svijeta. Trovanje školjkašima izazvano azaspiracidima slično je sindromu dijaretičkog trovanja školjkašima. Simptomi kao što su grčevi, povraćanje, mučnina i proljev javljaju se neposredno nakon konzumiranja. 1998. godine je utvrđena njegova prva struktura i do danas je uspješno izolirano barem 60 analoga. Informacije o toksikologiji su dobivene iz kontroliranih in vivo i in vitro eksperimenata. Metoda detekcije koje su se koristile za detekciju azaspiracida su: test na miševima koji je bio usvojen kao službeni test regulatornih laboratorija, danas je zamijenjem puno efikasnijom LC-MS metodom. Regulatorna dozvoljena doza azaspiracida u mesu školjkaša je 160 µg/kg.
Abstract (english)
Azaspiracids are a type of polyether toxins that were first discovered in 1995 in a poisoning incident in Ireland, where several people showed symptoms of poisoning after eating Mytilus edulis mussels. Their name is derived from their chemical properties: They contain a cyclic amino group (AZA group), three spiro groups (-SPIR-) and a carboxylic acid group (-ACID). Since then, numerous cases of poisoning due to the consumption of shellfish have been reported worldwide. Shellfish poisoning caused by azaspiracids is similar to the syndrome of diarrheic shellfish poisoning. Symptoms such as cramps, vomiting, nausea and diarrhea occur shortly after ingestion. in 1998, the first structure of azaspiracid was determined, and to date at least 60 analogs of this compound have been successfully isolated. The information on toxicology comes from controlled in vivo and in vitro experiments. Detection methods for the identification of azaspiracids include the mouse bioassay, a regulated test for toxins that has been largely replaced by the more effective LC-MS (liquid chromatography-mass spectrometry). The legally permitted dose for the consumption of azaspiracids is 160 µg/kg.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:721708
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2024-10-18 13:01:39