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Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans
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Marina Musa Aging is a process almost all known organisms undergo and it is accompanied by a general loss of function of all important physiological processes, including reduced resistance to cellular stress. While different stresses such as heat or oxidative stress are generally detrimental to the cell and the organism, if they are short and mild enough, they can benefit the organism and confer increased stress resistance later in life and prolong lifespan. This phenomenon is known as hormesis. By...
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Metodičko znanje o kemijskim vezama s naglaskom na jezična pitanja u Republici Hrvatskoj
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Roko Vladušić Prepoznajući važnost, ali i problematičnost razumijevanja modela kovalentnog i ionskog vezivanja, osmišljeno je i provedeno istraživanje o poteškoćama i nastavnim rješenjima za osnaživanje metodičkog znanja (MZ) o kemijskom vezivanju. Postavljena su tri cilja: (a) utvrditi studentsko razumijevanje određenih riječi i simbola koje se koristi u nastavi kemije te pratiti osviještenost budućih nastavnika o pozornosti koju treba pridati jeziku nastave kemije; (b) istražiti...
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Microheterogeneity in Ethanol-Water Mixture
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Marijana Mijaković Ethanol-water liquid mixture was analyzed by the method of Molecular Dynamics, over the whole composition range to elucidate its micro structure. A recently introduced concept of microheterogeneity was used to describe mixture's behaviour. It was discovered that there are at least three structural regimes with respect to composition range in aqueous ethanol at ambient conditions. Up to approximately 0.15 mole fraction of ethanol, hydrophobic ethanol's sites distribution declines from...
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Miskoncepcije i različiti pristupi poučavanju u uvodnoj nastavi programiranja kod učenika osnovne škole
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Žana Žanko Programiranje je poseban način razmišljanja kojim se od postavljenog problema dolazi do rješenja izvedivog na računalu. Upravo je zbog toga učenje programiranja danas tako važno. Istovremeno, ono je i zahtjevno, pa je prirodno tražiti načine kako ga olakšati primjenom različitih obrazovnih alata. Poučavanje programiranja bit će uspješnije ukoliko učitelji steknu uvid u ono što učenici znaju, ali također i u ono što ne znaju, pa je poznavanje najčešćih pogrešnih...
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Model poučavanja agentske paradigme korištenjem simulacijskih okruženja
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Krešimir Rakić Agentska paradigma objedinjuje istraživanja u kognitivnoj znanosti i umjetnoj inteligenciji. Uključivanje interaktivnih tehnologija, koje omogućavaju učenicima svih uzrasta aktivno sudjelovanje u relevantnim i autentičnim nastavnim aktivnostima, značajno doprinosi kvaliteti nastavnog procesa i usvajanju nastavnih sadržaja. Vizualizacija nastavnih sadržaja pomaže boljem razumijevanju i usvajanju gradiva, posebno u situacijama kad je prisutna visoka razina apstrakcije sadržaja. Ne...
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Modifying the proteostasis status: the role of cross-organelle communication
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Matea Kanunnikau Perpetual exposure to fluctuating intrinsic and environmental conditions constitute a challenge for maintaining a stable proteome, and this predicament is surmounted by an intricate system of precisely controlled mechanisms that constitute proteostasis. Proteostasis, or protein homeostasis, is orchestrated by an elaborate interlock of signaling pathways collectively known as the proteostasis network, with molecular chaperones constituting its most prominent component. The compartmentalized...
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On the nature of structural fluctuations in complex liquids
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Martina Požar The analysis of different types of structuring, present in simple and complex liquids and their mixtures, was done using the method of molecular dynamics. Complex mixtures have at least one associative component, such as water, alcohols (mono-ols and diols) and amines. The supra-molecular structuring in these mixtures is detected, described, quantified and connected with the atom-atom interactions is the molecules. These systems have interesting fluctuation behaviors, as shown through...
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Optical properties of noble metal nanocluster hybrids and their potential for biosensing
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Željka Sanader Maršić Linear and nonlinear optical properties of functionalized forms of noble metal nanoclusters are addressed in this thesis. Noble metal nanoclusters belong to nonscalable regime in which each atom counts. They exhibit molecular like electronic transitions, due to quantum confinement effects, which are strongly influenced by structure. These systems have potential for applications in biosensing and bioimaging, based on their unique optical, electronic and structural properties, after being...
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Otkrivanje genetičkih čimbenika povezanih s ukupnom razinom hormona štitne žlijezde u serumu
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Ivana Gunjača Hormoni štitnjače su neophodni za normalan rast, razvoj i metabolizam svake stanice u tijelu. Štitna žlijezda proizvodi dva hormona, tiroksin (\(T_{4}\)) i trijodtironin (\(T_{3}\)), i izlučuje ih u krvotok gdje je najveći dio hormona štitnjače vezan na proteinske nosače dok oko 0,03 % ukupnog \(T_{4}\) i 0,3 % ukupnog \(T_{3}\) u serumu cirkulira u slobodnom, nevezanom obliku. Serumski parametri štitnjače pokazuju značajnu raznolikost između zdravih pojedinaca koja je, pored...
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