prikaz prve stranice dokumenta Microfluidic chip for the sample derivatization prior to mass spectrometry
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master's thesis
Microfluidic chip for the sample derivatization prior to mass spectrometry
2019. urn:nbn:hr:166:872656
Mardešić, Ivan
University of Split
Faculty of Science
Department of Physics

Cite this document

Mardešić, I. (2019). Microfluidic chip for the sample derivatization prior to mass spectrometry (Master's thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:872656

Mardešić, Ivan. "Microfluidic chip for the sample derivatization prior to mass spectrometry." Master's thesis, University of Split, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:872656

Mardešić, Ivan. "Microfluidic chip for the sample derivatization prior to mass spectrometry." Master's thesis, University of Split, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:872656

Mardešić, I. (2019). 'Microfluidic chip for the sample derivatization prior to mass spectrometry', Master's thesis, University of Split, Faculty of Science, accessed 05 March 2025, https://urn.nsk.hr/urn:nbn:hr:166:872656

Mardešić I. Microfluidic chip for the sample derivatization prior to mass spectrometry [Master's thesis]. Split: University of Split, Faculty of Science; 2019 [cited 2025 March 05] Available at: https://urn.nsk.hr/urn:nbn:hr:166:872656

I. Mardešić, "Microfluidic chip for the sample derivatization prior to mass spectrometry", Master's thesis, University of Split, Faculty of Science, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:166:872656

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Metadata
TitleMicrofluidic chip for the sample derivatization prior to mass spectrometry
Title (croatian)Mikrofluidni čip za derivatizaciju uzorka prije masene spektrometrije
AuthorIvan Mardešić
MentorAnte Bilušić (mentor)
MentorKlaus Stefan Drese https://orcid.org/0000-0001-8829-1161 (pomoć pri izradi, neposredni voditelj)
Committee memberAnte Bilušić (predsjednik povjerenstva)
Committee memberLarisa Zoranić (član povjerenstva)
Committee memberMarija Raguž (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Physics)
Split
Defense date and country2019-09-12, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract
This is a paper on designing and making a microfluidic chip that would be used for hydrogendeuterium exchange to proteins and after chemical reaction, by mass spectrometry to observe the results of mass spectrometry. There are many factors to making this chip such as flows, reaction times, material, mixing of liquids, equipment available for work, etc. Ultimately three chemical reactions will occur in the chip and at the end of the chip output will be at a given flow for mass spectrometry. The motivation for this work is the automation process and to reduce costs of future research. Automation will improve and accelerate these studies and reduce the errors in protein research, and cheaper research could help make this method available to as many institutes and universities as possible, accelerating the research of protein and hydrogen-deuterium exchange.
Abstract (croatian)
Za ovaj rad napravljen je mikrofluidni čip koji bi služio za derivatizaciju proteina, te sve kemijske reakcije potrebne za dobivanje rezultata masene spektrometrije. U proteinu bi se vodik zamjenio deuterijem te gledao rezultat pomaka mase. Kod dizajna i pravljenja čipa mora se paziti na faktore kao što su: tokovi, vrijeme reakcije, materijali i metode dostupne za rad, miješanje tekućina itd. U radu će biti izračunate teoretske vrijednosti fizikalnih veličina i opisane metode pravljenja čipa te eksperimentalno testiranje teorijskih veličina. Motivacija za ovaj rad je smanjenje troškova u budućim istraživanja proteina masenom spektrometrijom kombinirana sa zamjena vodika s deuterijem.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:166:872656
Study programmeTitle: Physics; specializations in: major in teaching, major in Astrophysics, major in Biophysics, major in Enviromental physics, major in Computational physics
Course: major in Biophysics
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra fizike (magistar/magistra fizike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) icon
Created on2019-11-06 10:00:55