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undergraduate thesis
Biokemija niacina i učinak kod dislipidemije
2024. urn:nbn:hr:166:857318
Pavlović, Ivana
University of Split
Faculty of Science

Cite this document

Pavlović, I. (2024). Biokemija niacina i učinak kod dislipidemije (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:857318

Pavlović, Ivana. "Biokemija niacina i učinak kod dislipidemije." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:857318

Pavlović, Ivana. "Biokemija niacina i učinak kod dislipidemije." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:857318

Pavlović, I. (2024). 'Biokemija niacina i učinak kod dislipidemije', Undergraduate thesis, University of Split, Faculty of Science, accessed 28 November 2024, https://urn.nsk.hr/urn:nbn:hr:166:857318

Pavlović I. Biokemija niacina i učinak kod dislipidemije [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2024 [cited 2024 November 28] Available at: https://urn.nsk.hr/urn:nbn:hr:166:857318

I. Pavlović, "Biokemija niacina i učinak kod dislipidemije", Undergraduate thesis, University of Split, Faculty of Science, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:166:857318

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Metadata
TitleBiokemija niacina i učinak kod dislipidemije
Title (english)Niacin biochemistry and effects in dyslipidemia
AuthorIvana Pavlović
MentorViljemka Bučević Popović (mentor)
Committee memberViljemka Bučević Popović (predsjednik povjerenstva)
Committee memberMatilda Šprung (član povjerenstva)
Committee memberStjepan Orhanović (član povjerenstva)
GranterUniversity of Split
Faculty of Science
Split
Defense date and country2024-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Niacin, poznat i kao vitamin B3, ključan je za ljudski metabolizam kao prekursor koenzima NAD(H) i NADP(H). Ovi koenzimi sudjeluju u preko 400 enzimskih reakcija, uključujući metabolizam glukoze, masnih kiselina i kolesterola. Niacin se može unositi prehranom ili sintetizirati iz triptofana.Biosinteza NAD+ odvija se kroz de novo sintezu, Preiss-Handlerov put i Salvage put, te recikliranje NAD+ kako bi se održale optimalne razine niacina u stanicama. Nedostatak niacina može uzrokovati pelagru i ostale bolesti s ozbiljnim posljedicama. Niacin se koristi za liječenje dislipidemije, jer snižava LDL-kolesterol i trigliceride te povećava HDL-kolesterol. Iako su moguće nuspojave poput crvenila kože i probavnih smetnji, moderni pripravci s produljenim oslobađanjem smanjuju te nuspojave. Niacin ostaje važan lijek u prevenciji i liječenju kardiovaskularnih bolesti te pokazuje potencijal za širu medicinsku primjenu.
Abstract (english)
Niacin, also known as vitamin B3, is essential for human metabolism as a precursor of the coenzymes NAD(H) and NADP(H). These coenzymes participate in over 400 enzymatic reactions, including the metabolism of glucose, fatty acids, and cholesterol. Niacin can be obtained from diet or synthesized from tryptophan. NAD+ biosynthesis occurs through de novo synthesis, the Preiss-Handler pathway, and the Salvage pathway, as well as NAD+ recycling to maintain optimal niacin levels in cells. Niacin deficiency can lead to pellagra and other serious diseases. Niacin is used to treat dyslipidemia by lowering LDL cholesterol and triglycerides and raising HDL cholesterol. Although side effects such as skin flushing and digestive issues are possible, modern extended-release formulations reduce these effects. Niacin remains an important drug in the prevention and treatment of cardiovascular diseases and shows potential for broader medical applications.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:857318
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2024-09-27 07:24:06