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master's thesis
Optimization and in-depth analysis of alginate nanocellulose hydrogels for 3D printing of vascular and integumentary systems
2023. urn:nbn:hr:166:642604
Šurina, Paola
University of Split
Faculty of Science
Department of Chemistry

Cite this document

Šurina, P. (2023). Optimization and in-depth analysis of alginate nanocellulose hydrogels for 3D printing of vascular and integumentary systems (Master's thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:642604

Šurina, Paola. "Optimization and in-depth analysis of alginate nanocellulose hydrogels for 3D printing of vascular and integumentary systems." Master's thesis, University of Split, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:166:642604

Šurina, Paola. "Optimization and in-depth analysis of alginate nanocellulose hydrogels for 3D printing of vascular and integumentary systems." Master's thesis, University of Split, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:166:642604

Šurina, P. (2023). 'Optimization and in-depth analysis of alginate nanocellulose hydrogels for 3D printing of vascular and integumentary systems', Master's thesis, University of Split, Faculty of Science, accessed 10 May 2024, https://urn.nsk.hr/urn:nbn:hr:166:642604

Šurina P. Optimization and in-depth analysis of alginate nanocellulose hydrogels for 3D printing of vascular and integumentary systems [Master's thesis]. Split: University of Split, Faculty of Science; 2023 [cited 2024 May 10] Available at: https://urn.nsk.hr/urn:nbn:hr:166:642604

P. Šurina, "Optimization and in-depth analysis of alginate nanocellulose hydrogels for 3D printing of vascular and integumentary systems", Master's thesis, University of Split, Faculty of Science, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:166:642604

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Metadata
TitleOptimization and in-depth analysis of alginate nanocellulose hydrogels for 3D printing of vascular and integumentary systems
Title (croatian)Optimizacija i dubinska analiza alginatnih nanoceluloznih hidrogelova za 3D printanje krvožilnih i kožnih sustava
AuthorPaola Šurina
MentorPerica Bošković (mentor)
MentorRupert Kargl https://orcid.org/0000-0003-4327-7053 (pomoć pri izradi, neposredni voditelj)
Committee memberPerica Bošković (predsjednik povjerenstva)
Committee memberIvica Ljubenkov (član povjerenstva)
Committee memberMartina Gudelj (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Chemistry)
Split
Defense date and country2023-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
In recent decades, tissue engineering and regenerative medicine have received much attention. Although tissue engineering covers a wide range of applications, this work focuses mainly on the optimization and processing of hydrogels for such applications. Numerous properties of 3D printed and crosslinked alginate and nanocellulose hydrogels were analyzed, such as the calcium leaching process important for tissue regeneration processes, tensile properties to gain insight into the elastic and/or plastic properties of materials important for pressurized vascular systems, diffusion processes to demonstrate the permeability of the scaffolds for the transfer of nutrients to the cells and testing of the cytotoxicity of the material. Important biomaterial properties such as biocompatibility and controlled degradation for biomedical applications have been reached and optimized. It was observed that higher calcium concentration positively influences mechanical properties of the hydrogels. During tensile testing as well as shrinking and swelling tests, material anisotropy important for application in vascular systems was observed. The obtained results are promising for future applications in biomedicine and tissue engineering.
Abstract (croatian)
U zadnjih nekoliko desetljeća velika pažnja usmjerena je na inženjering tkiva i regenerativnu medicinu. Iako tkivni inženjering uključuje širok spektar primjena, ovaj rad fokusira se uglavnom na optimizaciju i razvoj hidrogelova za takvu primjenu. Analizirana su brojna svojstva 3D isprintanih i umreženih alginatnih i nanoceluloznih hidrogelova kao što su proces ispiranja kalcija važnog za procese regeneracije tkiva, zatim ispitivanja vlačnim povlačnjem kako bi se dobio uvid u elastična, odnosno plastična svojstva materijala važna za primjenu u krvožilnim sustavima. Zatim, pocesi difuzije za dokazivanje permeabilnosti hidrogela, vrlo važnog svojstva koje omogućuje prijenos nutrijenata do oštećenog tkiva, te na kraju ispitivanje citotoksičnosti materijala. Postignuta su i optimizirana važna svojstva biomaterijala za biomedicinske primjene, kao što su biokompatibilnost i kontrolirana degradacija. Uočeno je da veća koncentracija kalcija pozitivno utječe na mehanička svojstva hidrogelova. Tijekom testova rastezanja te testova bubrenja i skupljanja uočena je anizotropija materijala važna kod primjene u krvožilnim sustavima. Dobiveni rezultati obećavajući su za buduće primjene u biomedicini i tkivnom inženjeringu.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:166:642604
Study programmeTitle: Biology and Chemistry; specializations in: major in teaching
Course: major in teaching
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra edukacije biologije i kemije (magistar/magistra edukacije biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-10-03 10:48:50