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undergraduate thesis
Sinteza enantiomera kvarterne amonijeve soli 3-aminokinuklidina s dugim alkilnim lancem
2022. urn:nbn:hr:166:365996
Žeravica, Ileana
University of Split
Faculty of Science
Department of Chemistry

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Žeravica, I. (2022). Sinteza enantiomera kvarterne amonijeve soli 3-aminokinuklidina s dugim alkilnim lancem (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:365996

Žeravica, Ileana. "Sinteza enantiomera kvarterne amonijeve soli 3-aminokinuklidina s dugim alkilnim lancem." Undergraduate thesis, University of Split, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:166:365996

Žeravica, Ileana. "Sinteza enantiomera kvarterne amonijeve soli 3-aminokinuklidina s dugim alkilnim lancem." Undergraduate thesis, University of Split, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:166:365996

Žeravica, I. (2022). 'Sinteza enantiomera kvarterne amonijeve soli 3-aminokinuklidina s dugim alkilnim lancem', Undergraduate thesis, University of Split, Faculty of Science, accessed 07 May 2024, https://urn.nsk.hr/urn:nbn:hr:166:365996

Žeravica I. Sinteza enantiomera kvarterne amonijeve soli 3-aminokinuklidina s dugim alkilnim lancem [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2022 [cited 2024 May 07] Available at: https://urn.nsk.hr/urn:nbn:hr:166:365996

I. Žeravica, "Sinteza enantiomera kvarterne amonijeve soli 3-aminokinuklidina s dugim alkilnim lancem", Undergraduate thesis, University of Split, Faculty of Science, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:166:365996

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Metadata
TitleSinteza enantiomera kvarterne amonijeve soli 3-aminokinuklidina s dugim alkilnim lancem
Title (english)Synthesis of enantiomers of 3-aminoquinuclidine quarternary salt with long alkyl chain
AuthorIleana Žeravica
MentorRenata Odžak (mentor)
Committee memberRenata Odžak (predsjednik povjerenstva)
Committee memberMarina Kranjac (član povjerenstva)
Committee memberLinda Mastelić (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Chemistry)
Split
Defense date and country2022-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Kvarterne amonijeve soli koriste se kao biološki indikatori, surfaktanti i terapeutici te se često nalaze u sastavu raznih kozmetičkih proizvoda, primjerice šampona i sapuna. Osim toga, sve je češća primjena kvarternih amonijevih soli kao antiseptika te kao antimikrobnih agensa. U svrhu daljnjih bioloških istraživanja, sintetizirani su (R)- i (S)-enantiomeri kvarterne amonijeve soli 3-aminokinuklidina. Kinuklidin je biciklički spoj koji u premoštenju sadrži dušikov atom koji je radi svoje bazičnosti podložan reakciji kvaternizacije, a 3-aminokinuklidin je supstituirani kinuklidin s amino skupinom na trećem ugljikovom atomu. Za kvaternizaciju enantiomera korišten je 1-bromtetradekan. Navedeni alkil-halogenid ima atom broma koji je u reakciji kvaternizacije dobra izlazna skupina. Nastali enantiomeri su bijele krutine dobivene u dobrom iskorištenju. Čistoća novosintetiziranih kvarternih amonijevih soli je analizirana i potvrđena tehnikom tankoslojne kromatografije.
Abstract (english)
Quarternary ammonium salts are used as biological indicators, surfactants and therapeutics, and they are commonly found in many cosmetic products such as shampoos and soaps. Furthermore, quarternary ammonium salts are increasingly used as antiseptics and antimicrobial agents. For the purpose of further biological research, the (R)- and (S)-enantiomers of the quarternary ammonium salt 3-aminoquinuclidine were synthesized. Quinuclidine is a bicyclic compound with a bridgehead nitrogen atom that is subject to quaternization due to its basicity, and 3-aminoquinuclidine is a supstituted quinuclidine with an amino group on the third carbon atom. For the quaternization of enantiomers, 1-bromotetradecane has been used. The used alkyl halide contains a bromine atom which in a reaction of quaternization acts as a good leaving group. The products are white solids obtained in good yields. The purity of the newly synthesized quarternary ammonium salts was analysed and confirmed by thin layer chromatography.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:365996
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-12-19 13:01:06