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undergraduate thesis
Oksidacijsko oštećenje proteina
2018. urn:nbn:hr:166:703787
Perković, Matea
University of Split
Faculty of Science
Department of Chemistry

Cite this document

Perković, M. (2018). Oksidacijsko oštećenje proteina (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:703787

Perković, Matea. "Oksidacijsko oštećenje proteina." Undergraduate thesis, University of Split, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:166:703787

Perković, Matea. "Oksidacijsko oštećenje proteina." Undergraduate thesis, University of Split, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:166:703787

Perković, M. (2018). 'Oksidacijsko oštećenje proteina', Undergraduate thesis, University of Split, Faculty of Science, accessed 18 April 2024, https://urn.nsk.hr/urn:nbn:hr:166:703787

Perković M. Oksidacijsko oštećenje proteina [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2018 [cited 2024 April 18] Available at: https://urn.nsk.hr/urn:nbn:hr:166:703787

M. Perković, "Oksidacijsko oštećenje proteina", Undergraduate thesis, University of Split, Faculty of Science, Split, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:166:703787

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Metadata
TitleOksidacijsko oštećenje proteina
Title (english)Oxidative protein damage
AuthorMatea Perković
MentorViljemka Bučević Popović (mentor)
Committee memberViljemka Bučević Popović (predsjednik povjerenstva)
Committee memberMaja Pavela Vrančić (član povjerenstva)
Committee memberStjepan Orhanović (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Chemistry)
Split
Defense date and country2018-06-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U radu je opisano oksidacijsko oštećenje proteina i oksidacijski stres - poremećaj ravnoteže između proizvodnje reaktivnih kisikovih radikala i antioksidansa u organizmu. Reaktivne kisikove vrste (ROS) i reaktivne dušikove vrste (RNS) su pojmovi koji opisuju slobodne radikale i čestice koje nisu slobodni radikali, a također imaju oksidacijsko djelovanje. Najveća količina reaktivnih kisikovih vrsta u obliku O₂.- nastaje svakodnevno u mitohondrijskom lancu za prijenos elektrona. Oksidacija proteina može rezultirati stvaranjem proteinskih karbonila. Reaktivne vrste kisika mogu izravno reagirati s pojedinim aminokiselinskim ostacima ili dovesti do oksidacijskog cijepanja polipeptidne okosnice. Druge moguće tvorbe proteinskih karbonila su putem oksidacije lipida ili preko reakcije redukcijskih šećera. Opisani su biomarkeri oksidacijskog stresa i antioksidacijske obrane, metode određivanja karboniliranih proteina, te veza između oksidacijskog stresa i bolesti povezanih sa starenjem.
Abstract (english)
This thesis describes oxidative protein damage and oxidative stress - an imbalance between reactive oxygen radicals and antioxidants in the organism. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are terms collectively describing free radicals and other nonradical reactive derivatives, which also have oxidant activity. The largest amount of reactive oxygen species in the form O₂.- is generate daily in the mitochondrial electron trasport chain. Protein oxidation may result in protein carbonyl formation. Reactive oxygen species may either react directly with some amino acid residues or lead to oxidative cleavage of the protein backbone. Other possible formation of protein carbonyls is via oxidation of lipids or there reaction of reducing sugars. Biomarkers of oxidative stress and antioxidant defence are described, as well as the methods of protein carbonyls determination and the associations between oxidative stress and age-related diseases.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:703787
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2019-02-01 16:18:09