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undergraduate thesis
Replikacija DNA i održavanje stabilnosti genoma
2018. urn:nbn:hr:166:160978
Vuković, Mila
University of Split
Faculty of Science
Department of Physics

Cite this document

Vuković, M. (2018). Replikacija DNA i održavanje stabilnosti genoma (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:160978

Vuković, Mila. "Replikacija DNA i održavanje stabilnosti genoma." Undergraduate thesis, University of Split, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:166:160978

Vuković, Mila. "Replikacija DNA i održavanje stabilnosti genoma." Undergraduate thesis, University of Split, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:166:160978

Vuković, M. (2018). 'Replikacija DNA i održavanje stabilnosti genoma', Undergraduate thesis, University of Split, Faculty of Science, accessed 14 November 2024, https://urn.nsk.hr/urn:nbn:hr:166:160978

Vuković M. Replikacija DNA i održavanje stabilnosti genoma [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2018 [cited 2024 November 14] Available at: https://urn.nsk.hr/urn:nbn:hr:166:160978

M. Vuković, "Replikacija DNA i održavanje stabilnosti genoma", Undergraduate thesis, University of Split, Faculty of Science, Split, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:166:160978

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Metadata
TitleReplikacija DNA i održavanje stabilnosti genoma
Title (english)DNA replication and maintenance of genome stability
AuthorMila Vuković
MentorIvica Šamanić (mentor)
Committee memberIvica Šamanić (predsjednik povjerenstva)
Committee memberLarisa Zoranić (član povjerenstva)
Committee memberLucija Krce (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Physics)
Split
Defense date and country2018-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract
U radu je najprije prikazan mehanizam replikacije DNA eukariotskih stanica. Sinteza molekule DNA bazirana je na specifičnom Watson-Crick sparivanju baza koje predstavljaju jedan od najvažnijih motiva u sekundarnoj strukturi DNA. Termodinamika stvaranja parova baza opisana je modelom najbližih susjeda (engl. nearest neigbor model). Kromosomi eukariotskih stanica su linearni i dugački pa su time često podložni stvaranju različitih neuobičajenih struktura koje ometaju replikacijske rašlje ali često i olakšavaju procese u koje je uključena molekula DNA. Zbog toga su opisane osnove topologije i najčešće alternativne strukture DNA strukture. Zadaci koji se moraju izvršiti tijekom replikacije zahtijevaju međusobnu koordinaciju i stoga nije iznenađujuće da defekti u replikaciji DNA uzrokuju brojne ljudske bolesti. Iz tog razloga opisana je kontrola staničnog ciklusa i mehanizmi koji omogućavaju zaobilaženje mjesta oštećenja.
Abstract (english)
This thesis first presents the mechanism of replication of eukaryotic cells. DNA synthesis is based on specific Watson-Crick base pairing, which provide a simple structural code of DNA secondary structure formation. Nearest-neighbor model predict the thermodynamic parameters for for Watson-Crick base pairs. Long linear eukaryotic chromosomes are often susceptible to creating unusual DNA structures that can cause stalling of replication fork but often they can facilitate certain DNA processes. Therefore, the principles of DNA topology and the most common alternative DNA structures are described. Many complex tasks that must be performed during DNA replication require co-ordination and accordingly it is not surprising that defects in DNA replication cause many human diseases. For this reason, the cell cycle control mechanisms and damage tolerance pathways are described as following.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:160978
Study programmeTitle: Physics
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) fizike (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) fizike)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-12-18 15:25:57