Bakterijska rezistencija na antibiotike Acinetobacter izolata iz uređaja za otpadne vode u Hrvatskoj

Embargo period 2028-02-11

master's thesis

Budić Leto, Bruna

University of Split
Faculty of Science

Cite this document

APA 6th Edition

Budić Leto, B. (2025). Bakterijska rezistencija na antibiotike Acinetobacter izolata iz uređaja za otpadne vode u Hrvatskoj (Master's thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:596293

MLA 8th Edition

Budić Leto, Bruna. "Bakterijska rezistencija na antibiotike Acinetobacter izolata iz uređaja za otpadne vode u Hrvatskoj." Master's thesis, University of Split, Faculty of Science, 2025. https://urn.nsk.hr/urn:nbn:hr:166:596293

Chicago 17th Edition

Harvard

Budić Leto, B. (2025). 'Bakterijska rezistencija na antibiotike Acinetobacter izolata iz uređaja za otpadne vode u Hrvatskoj', Master's thesis, University of Split, Faculty of Science, accessed 15 February 2025, https://urn.nsk.hr/urn:nbn:hr:166:596293

Vancouver

Budić Leto B. Bakterijska rezistencija na antibiotike Acinetobacter izolata iz uređaja za otpadne vode u Hrvatskoj [Master's thesis]. Split: University of Split, Faculty of Science; 2025 [cited 2025 February 15] Available at: https://urn.nsk.hr/urn:nbn:hr:166:596293

IEEE

B. Budić Leto, "Bakterijska rezistencija na antibiotike Acinetobacter izolata iz uređaja za otpadne vode u Hrvatskoj", Master's thesis, University of Split, Faculty of Science, Split, 2025. Available at: https://urn.nsk.hr/urn:nbn:hr:166:596293

Cite this item: https://urn.nsk.hr/urn:nbn:hr:166:596293

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Title	Bakterijska rezistencija na antibiotike Acinetobacter izolata iz uređaja za otpadne vode u Hrvatskoj
Title (english)	Bacterial resistance to antibiotics in Acinetobacter isolates from wastewater treatment plants in Croatia
Author	Bruna Budić Leto
Mentor	Ana Maravić (mentor)
Mentor	Marija Kvesić Ivanković (komentor)
Committee member	Ana Maravić (predsjednik povjerenstva)
Committee member	Ivica Šamanić (član povjerenstva)
Committee member	Marija Kvesić Ivanković (član povjerenstva)
Granter	University of Split Faculty of Science Split
Defense date and country	2025-01-21, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Biology
Abstract	Cilj ovog istraživanja bio je ispitati fenotipsku osjetljivost izolata roda Acinetobacter na različite antibiotike. Uzorci vode su prikupljeni u uređajima za pročišćavanje otpadnih voda (UPOV) Katalinića brig i Stupe u Splitu, te na pripadajućim podmorskim ispustima. Ukupno je identificiran 91 izolat, među kojima su najzastupljeniji bili A. baumannii i A. pittii, dok su ostale vrste bile manje prisutne. Rezultati su pokazali značajnu razinu rezistencije na karbapeneme (meropenem, imipenem) i peniciline s inhibitorima β-laktamaze (piperacilin/tazobaktam, tikarcilin/klavulanska kiselina). A. baumannii je pokazao najveću učestalost rezistencije, dok je A. sichuaensis bio najosjetljiviji na testirane antibiotike. Najviša stopa rezistencije zabilježena je kod izolata iz influenta UPOV-a Katalinića brig, što može biti posljedica ulijevanja bolničkih otpadnih voda u ovaj UPOV. Naime, prethodne studije su pokazale da značajan selekcijski pritisak u takvim uvjetima povećava udio višestruko rezistentnih sojeva. Ovo istraživanje naglašava ulogu otpadnih voda kao rezervoara rezistentnih oportunističkih patogena, uključujući patogena kritičnog prioriteta, karbapenem-rezistentnog A. baumannii, kao i potrebu njihovog rigoroznog praćenja u cilju smanjenja javnozdravstvene prijetnje.
Abstract (english)	The aim of this study was to examine the phenotypic sensitivity of isolates of the genus Acinetobacter to different antibiotics. Samples were collected from wastewater treatment plants (WWTP) of Katalinić brig and Stupe in Split, including their submarine outfalls. A total of 91 isolates were identified, among which A. baumannii and A. pittii were the most abundant, while other species were less present. Results showed a significant level of resistance to carbapenems (meropenem, imipenem) and penicillins with β-lactamase inhibitors (piperacillin/tazobactam, ticarcillin/clavulanic acid). A. baumannii showed the highest resistance rate whereas A. sichuaensis was the most sensitive to the antibiotics used. The highest resistance rate was recorded for isolates from the influent of UPOV Katalinić brig, which could be attributed to the presence of hospital wastewater. It was previously found that the selection pressure under such conditions increases the proportion of multiple resistant strains. The study highlights the role of wastewater as a reservoir of antibiotic-resistant opportunistic pathogens, including the WHO critical-priority pathogens, the carbapenem-resistant A. baumannii, as well as the need for their rigorous monitoring to reduce the public health threat.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:166:596293
Study programme	Title: Biology and Chemistry; specializations in: specialization in Education Course: specialization in Education Study programme type: university Study level: graduate Academic / professional title: sveučilišni/a magistar/magistra edukacije biologije i kemije (sveučilišni/a magistar/magistra edukacije biologije i kemije)
Type of resource	Text
File origin	Born digital
Access conditions	Embargoed access Embargo expiration date: 2028-02-11
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Created on	2025-02-12 10:45:33