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undergraduate thesis
Primjena alkilirajućih spojeva u medicini
2024. urn:nbn:hr:166:498435
Topić, Ivona
University of Split
Faculty of Science

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Topić, I. (2024). Primjena alkilirajućih spojeva u medicini (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:498435

Topić, Ivona. "Primjena alkilirajućih spojeva u medicini." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:498435

Topić, Ivona. "Primjena alkilirajućih spojeva u medicini." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:498435

Topić, I. (2024). 'Primjena alkilirajućih spojeva u medicini', Undergraduate thesis, University of Split, Faculty of Science, accessed 14 November 2024, https://urn.nsk.hr/urn:nbn:hr:166:498435

Topić I. Primjena alkilirajućih spojeva u medicini [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2024 [cited 2024 November 14] Available at: https://urn.nsk.hr/urn:nbn:hr:166:498435

I. Topić, "Primjena alkilirajućih spojeva u medicini", Undergraduate thesis, University of Split, Faculty of Science, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:166:498435

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Metadata
TitlePrimjena alkilirajućih spojeva u medicini
Title (english)The application of alkylating agents in medicine
AuthorIvona Topić
MentorRenata Odžak (mentor)
Committee memberRenata Odžak (predsjednik povjerenstva)
Committee memberMatilda Šprung (član povjerenstva)
Committee memberDoris Crnčević (član povjerenstva)
GranterUniversity of Split
Faculty of Science
Split
Defense date and country2024-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Alkilirajući spojevi su skupina najčešće korištenih citostatika čija je primjena prvenstveno u kemoterapiji za liječenje različitih vrsta raka. Njihova aktivnost temelji se na kovalentnoj interakciji s molekulom DNA, odnosno terminalni atom ugljika alkilirajućih spojeva ostvaruje kovalentne veze s elektronima bogatim regijama različitih molekula. Posljedica njihova djelovanja jest inhibicija ili netočna replikacija DNA što dovodi i do mutacija ili stanične smrti. Budući da su vrlo raznoliki u svojim strukturama, mehanizmima djelovanja, specifičnosti, i dalje su glavna zanimacija svih znanstvenika. U alkilirajuće spojeve ubaraja se 5 velikih skupina: dušični iperiti, alkil alkan sulfonati, nitrozouree, aziridini i epoksidi, te derivati hidrazina i trizaina. Glavni mehanizam djelovanja svih alkilirajućih spojeva je nukleofilna supstitucija, a ovisno o samoj strukturi, ona može biti 1. ili 2. reda.
Abstract (english)
Alkylating agents are group of the most commonly used cytostatics whose application is primarily in chemotherapy for the treatment of various types of cancer. Their activity is based on covalent interaction with the DNA molecule, where the terminal carbon atom of alkylating compounds forms covalent bonds with electron-rich regions of different molecules. The consequence of their action is inhibition or incorrect DNA replication, which leads to mutations or cell death. Since they are very diverse in their structures, mechanisms of action, specificities, they are still the main interest of scientists. Alkylating compounds include 5 large groups: nitrogen mustards, alkyl alkane sulfonates, nitrosoureas, aziridines and epoxides, and hydrazine and trizaine derivatives. The main mechanism of action of all alkylating compounds is nucleophilic substitution, and depending on the structure itself, it can lead the 1st or 2nd order mechanism.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:498435
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2024-09-24 12:40:44