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undergraduate thesis
Antimikrobna aktivnost kvaternih fosfonijevih spojeva
2024. urn:nbn:hr:166:414772
Močić, Matea
University of Split
Faculty of Science
Department of Chemistry

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Močić, M. (2024). Antimikrobna aktivnost kvaternih fosfonijevih spojeva (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:414772

Močić, Matea. "Antimikrobna aktivnost kvaternih fosfonijevih spojeva." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:414772

Močić, Matea. "Antimikrobna aktivnost kvaternih fosfonijevih spojeva." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:414772

Močić, M. (2024). 'Antimikrobna aktivnost kvaternih fosfonijevih spojeva', Undergraduate thesis, University of Split, Faculty of Science, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:166:414772

Močić M. Antimikrobna aktivnost kvaternih fosfonijevih spojeva [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2024 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:166:414772

M. Močić, "Antimikrobna aktivnost kvaternih fosfonijevih spojeva", Undergraduate thesis, University of Split, Faculty of Science, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:166:414772

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Metadata
TitleAntimikrobna aktivnost kvaternih fosfonijevih spojeva
Title (english)Antimicrobial activity of quaternary phosphonium compounds
AuthorMatea Močić
MentorMatilda Šprung (mentor)
MentorDoris Crnčević (pomoć pri izradi, neposredni voditelj)
Committee memberMatilda Šprung (predsjednik povjerenstva)
Committee memberRenata Odžak (član povjerenstva)
Committee memberDoris Crnčević (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Chemistry)
Split
Defense date and country2024-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Antimikrobna rezistencija predstavlja globalni problem javno-zdravstvenog sustava. U borbi protiv mikroorganizama dosada su korišteni visoko djelotvorni kvaterni amonijevi spojevi (QACs). Porastom uporabe dezinficijensa i antiseptika niže koncentracije ovih spojeva završile su u otpadnim vodama pri čemu su bakterije u kontaktu s istima počele razvijati rezistenciju. U potrazi za novim antimikrobnim agensima sintetizirani su kvaterni fosfonijevi spojevi (QPCs). Njihova aktivnost pokazala je obećavajuće rezultate, stoga se znanost usmjerava prema sintezi novih inačica ovih spojeva. U ovom radu ispitana je antimikrobna aktivnost nekomercijalnih kvaternih fosfonijevih spojeva sintetiziranih na Prirodoslovno-matematičkom fakultetu u Splitu oznaka: TPP-BnAc, TPP-PhAc, TPP-Bn, TPP-16 i TPP-14. Ispitivanja su provedena na bakterijama Staphylococcus aureus ATCC 25923 i Escherichia coli ATCC 25922 koristeći metodu mikrodilucije. Ispitivanje je pokazalo da TPP-BnAc, TPP-PhAc i TPP-Bn posjeduju vrlo nisku antimikrobnu aktivnost, dok spojevi TPP-16 i TPP-14 imaju zadovoljavajuću antimikrobnu aktivnost, u skladu s dosadašnjom literaturom. Sve navedeno dovodi do zaključka da kvaterni fosfonijevi spojevi predstavljaju dobru polaznu točku za daljnji nastavak istraživanja u potrazi za novim antimikrobno djelotvornijim spojevima.
Abstract (english)
Antimicrobial resistance is a significant global public health threat. Quaternary ammonium compounds (QACs) have been widely used as highly effective agents against microorganisms. However, with the growing use of disinfectants and antiseptics, lower concentrations of these compounds have entered wastewater, leading bacteria to develop resistance. In response, researchers have focused on developing new antimicrobial agents, such as quaternary phosphonium compounds (QPCs), which have shown promising results. This thesis investigates the antimicrobial activity of non-commercial quaternary phosphonium compounds synthesized at the Faculty of Science in Split, specifically TPP-BnAc, TPP-PhAc, TPP-Bn, TPP-16, and TPP-14. Using the microdilution method, antimicrobial activity was determined on the bacteria Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The results revealed that TPP-BnAc, TPP-PhAc, and TPP-Bn exhibit low antimicrobial activity, while TPP-16 and TPP-14 display potent activity consistent with previous findings. These results suggest that quaternary phosphonium compounds offer a promising foundation for further research in the development of more effective antimicrobial agents.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:414772
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2024-09-20 12:34:42