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undergraduate thesis
Utjecaj fitoplanktonskih toksina na prijenos iona natrija kroz membranu neurona
2023. urn:nbn:hr:166:022322
Musić, Lina
University of Split
Faculty of Science
Department of Chemistry

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Musić, L. (2023). Utjecaj fitoplanktonskih toksina na prijenos iona natrija kroz membranu neurona (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:022322

Musić, Lina. "Utjecaj fitoplanktonskih toksina na prijenos iona natrija kroz membranu neurona." Undergraduate thesis, University of Split, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:166:022322

Musić, Lina. "Utjecaj fitoplanktonskih toksina na prijenos iona natrija kroz membranu neurona." Undergraduate thesis, University of Split, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:166:022322

Musić, L. (2023). 'Utjecaj fitoplanktonskih toksina na prijenos iona natrija kroz membranu neurona', Undergraduate thesis, University of Split, Faculty of Science, accessed 27 October 2024, https://urn.nsk.hr/urn:nbn:hr:166:022322

Musić L. Utjecaj fitoplanktonskih toksina na prijenos iona natrija kroz membranu neurona [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2023 [cited 2024 October 27] Available at: https://urn.nsk.hr/urn:nbn:hr:166:022322

L. Musić, "Utjecaj fitoplanktonskih toksina na prijenos iona natrija kroz membranu neurona", Undergraduate thesis, University of Split, Faculty of Science, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:166:022322

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Metadata
TitleUtjecaj fitoplanktonskih toksina na prijenos iona natrija kroz membranu neurona
Title (english)The effect of phytoplankton toxins on the transport of sodium ions through the neuron membrane
AuthorLina Musić
MentorStjepan Orhanović (mentor)
Committee memberStjepan Orhanović (predsjednik povjerenstva)
Committee memberViljemka Bučević Popović (član povjerenstva)
Committee memberBarbara Soldo (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Chemistry)
Split
Defense date and country2023-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Fitoplanktonski toksini su termostabilne, uglavnom neproteinske molekule malih do vrlo velikih molekulskih masa. Oko 75 vrsta fitoplanktona prirodno proizvode sekundarne metabolite koji su toksični za ljude i neke više organizme. Fitoplanktonski toksini se akumuliraju u organizmima koji se hrane filtracijom mora kao što su školjkaši pa konzumacijom takvih plodova mora dolazi do trovanja ljudi. Neki od fitoplanktonskih toksina djeluju na naponom regulirane natrijev kanale. Natrijevi kanali regulirani naponom ključni su za stvaranje i prijenos akcijskih potencijala u stanicama kao što su neuroni i mišićne stanice. Postoji osam karakterističnih mjesta u strukturi kanala na koja se vežu mnogi toksini, uključujući nekoliko skupina fitoplanktonskih. Toksini koji djeluju na natrijeve kanale regulirane naponom su saksitoksini, tetrodotoksini, brevetoksini i ciguatoksini. Brevetoksini i ciguatoksini vežu se na mjesto 5 natrijevih kanala reguliranih naponom, dok se saksitoksini i tetrodotoksin vežu za mjesto 1. Ciguatoksini i brevetoksini održavaju natrijeve kanale regulirane naponom u trajno otvorenom obliku, dok saksitoksini, i tetrodotoksini blokiraju ulazak Na+ iona. Zato oni imaju analgetska svojstva te je njihova primjena kao lijekova protiv bolova predmet istraživanja u farmakologiji.
Abstract (english)
Phytoplankton toxins are thermostable, mostly non-protein molecules with small to very large molecular masses. About 75 species of phytoplankton naturally produce secondary metabolites that are toxic to humans and some higher organisms. Phytoplankton toxins accumulate in organisms that feed by the filtration of the sea, such as bivalves, so the consumption of such seafood leads to poisoning in humans. Some of the phytoplankton toxins act on voltage-gated sodium channels. Voltage-gated sodium channels are crucial for the generation and transmission of action potentials in cells such as neurons and muscle cells. There are eight characteristic sites in the channel structure to which many toxins bind, including several groups of phytoplankton toxins. Toxins that act on voltage-gated sodium channels are saxitoxins, tetrodotoxins, brevetoxins, and ciguatoxins. Brevetoxins and ciguatoxins bind to site 5 of voltage-gated sodium channels, whereas saxitoxins and tetrodotoxins bind to site 1. Ciguatoxins and brevetoxins maintain voltage-gated sodium channels in a permanently open form, while saxitoxins and tetrodotoxins block Na+ entry. That is why they have analgesic properties and their use as painkillers is the subject of research in pharmacology.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:022322
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-09-28 11:29:55