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master's thesis
Electronic Properties Of The Protein From The Oxidoreductase Family
2023. urn:nbn:hr:166:651805
Matekalo, Jelena
University of Split
Faculty of Science
Department of Physics

Cite this document

Matekalo, J. (2023). Electronic Properties Of The Protein From The Oxidoreductase Family (Master's thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:651805

Matekalo, Jelena. "Electronic Properties Of The Protein From The Oxidoreductase Family." Master's thesis, University of Split, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:166:651805

Matekalo, Jelena. "Electronic Properties Of The Protein From The Oxidoreductase Family." Master's thesis, University of Split, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:166:651805

Matekalo, J. (2023). 'Electronic Properties Of The Protein From The Oxidoreductase Family', Master's thesis, University of Split, Faculty of Science, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:166:651805

Matekalo J. Electronic Properties Of The Protein From The Oxidoreductase Family [Master's thesis]. Split: University of Split, Faculty of Science; 2023 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:166:651805

J. Matekalo, "Electronic Properties Of The Protein From The Oxidoreductase Family", Master's thesis, University of Split, Faculty of Science, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:166:651805

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Metadata
TitleElectronic Properties Of The Protein From The Oxidoreductase Family
Title (croatian)Elektronska svojstva proteina iz klase oksidoreduktaza
AuthorJelena Matekalo
MentorŽeljka Sanader Maršić (mentor)
MentorMartina Perić Bakulić (pomoć pri izradi, neposredni voditelj)
Committee memberŽeljka Sanader Maršić (predsjednik povjerenstva)
Committee memberBernarda Lovrinčević (član povjerenstva)
Committee memberMartina Perić Bakulić (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Physics)
Split
Defense date and country2023-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract
Electron transfer between the redox protein PQQ-GDH and carbon nanotubes, acting as a bioelectrode, has been accomplished in recent decades. In this time, the focus has been on investigating the suitability of carbon nanotubes as bioelectrodes. The reason for this lies in the biomedical applications, specifically the electron transfer between proteins and bioelectrodes, which forms the basis for the development of small medical devices. In cells, proteins are found in the cellular medium and mostly have free movement. However, to become a part of a bioelectrode, they need to be immobilized on the surface. Therefore, it is crucial to thoroughly understand the mechanism of their activity in order to influence this activity and ensure that enzymes remain active even when immobilized. The initiation of this research involves observing the electronic structure of the active site of the PQQ-GDH system before and after the electron transfer reaction occurs. The study was conducted using the Density Functional Theory (DFT) method, a Quantum Mechanical (QM) method, to determine the molecular geometry and electronic structure of the molecular system.
Abstract (croatian)
Prijenos elektrona između redoks proteina PQQ-GDH i ugljikove nanocijevi, koja djeluje kao bioelektroda, značajno je područje istraživanja je u posljednjih nekoliko desetljeća. U ovom razdoblju fokus je na ispitivanju prikladnosti ugljikovih nanocijevi kao bioelektroda. Razlog tome je biomedicinske prirode, odnosno prijenos elektrona između proteina i bioelektroda temelj je razvoja malih medicinskih uređaja. U stanicama proteini se nalaze u staničnom mediju i većinom imaju slobodno gibanje. Međutim, da bi bili dio bioelektroda, moraju biti imobilizirani na površini. Zato je bitno rauzmjeti detaljno mehanizam njihove aktivnosti, kako bi se moglo utjecati na tu aktivnost i osigurati da su enzimi aktivni i kad su imobilizirani. Začetak ovog istraživanja je na promatranju elektronske strukture aktivnog mjesta sustava proteina pirolokinolin kinon ovisna glukoza dehidrogenaza (PQQ-GDH) prije te nakon što se dogodi reakcija prijenosa elektrona. Istraživanje je odrađeno metodom teorije funkcionala gustoće (DFT), jednom od metoda kvantne mehanike, kojom je određena molekularna geometrija te elektronska struktura proučavanog molekularnog sustava.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:166:651805
Study programmeTitle: Physics; specializations in: major in teaching, major in Astrophysics, major in Biophysics, major in Enviromental physics, major in Computational physics, major in Astrophysics and physics of elemental particles
Course: major in Biophysics
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra fizike (magistar/magistra fizike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-09-25 12:50:34