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undergraduate thesis
Komercijalne kvaterne amonijeve soli - potencijalni supstrati Qac efluks pumpi
2022. urn:nbn:hr:166:939068
Ćurić, Lucijana
University of Split
Faculty of Science
Department of Chemistry

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Ćurić, L. (2022). Komercijalne kvaterne amonijeve soli - potencijalni supstrati Qac efluks pumpi (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:939068

Ćurić, Lucijana. "Komercijalne kvaterne amonijeve soli - potencijalni supstrati Qac efluks pumpi." Undergraduate thesis, University of Split, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:166:939068

Ćurić, Lucijana. "Komercijalne kvaterne amonijeve soli - potencijalni supstrati Qac efluks pumpi." Undergraduate thesis, University of Split, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:166:939068

Ćurić, L. (2022). 'Komercijalne kvaterne amonijeve soli - potencijalni supstrati Qac efluks pumpi', Undergraduate thesis, University of Split, Faculty of Science, accessed 26 April 2024, https://urn.nsk.hr/urn:nbn:hr:166:939068

Ćurić L. Komercijalne kvaterne amonijeve soli - potencijalni supstrati Qac efluks pumpi [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2022 [cited 2024 April 26] Available at: https://urn.nsk.hr/urn:nbn:hr:166:939068

L. Ćurić, "Komercijalne kvaterne amonijeve soli - potencijalni supstrati Qac efluks pumpi", Undergraduate thesis, University of Split, Faculty of Science, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:166:939068

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Metadata
TitleKomercijalne kvaterne amonijeve soli - potencijalni supstrati Qac efluks pumpi
Title (english)Commercial quaternary ammonium salts - potential substrates for Qac efflux pumps
AuthorLucijana Ćurić
MentorMatilda Šprung (mentor)
MentorDoris Crnčević (pomoć pri izradi, neposredni voditelj)
Committee memberMatilda Šprung (predsjednik povjerenstva)
Committee memberStjepan Orhanović (član povjerenstva)
Committee memberDoris Crnčević (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Chemistry)
Split
Defense date and country2022-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Razvoj rezistentnih sojeva bakterija predstavlja globalnu opasnost. Stoga istraživanja novih antimikrobnih spojeva često obuhvaćaju ispitivanje potencijala razvoja rezistencije kao i rezistentnih mehanizama. Kvaterne amonijeve soli (engl. quaternary ammonium compounds, QACs) antimikrobni su reagensi širokog spektra djelovanja. Istraživanja su pokazala da je razvoj rezistencije prema QACs najčešće posredovan efluks pumpama Qac. U ovom završnom radu ispitan je antimikrobni potencijal komercijalnih QACs, cetilpiridinijevog klorida i benzalkonijevog bromida, kao i njihov potencijal razvoja rezistencije posredovan Qac efluks pumpama. Ispitivanja su provedena na bakteriji Staphylococcus aureus ATCC 33591 pri čemu su određene minimalne inhibitorne koncentracije (MIK) ovih spojeva bez i u prisustvu inhibitora ATP-sintaze, karbonil cijanid m-klorofenil hidrazona. Dobiveni rezultati upućuju na zaključak da su oba komercijalna QACs spoja supstrati Qac efluks pumpi što potvrđuje objavljene podatke o sve široj incidenciji rezistencije prema ovim spojevima.
Abstract (english)
The development of resistant strains of bacteria represents a global danger. Therefore, research into new antimicrobial compounds often includes testing the potential for resistance development as well as resistance mechanisms. Quaternary ammonium compounds (QACs) are antimicrobial reagents with a wide spectrum of action. Research has shown that the development of resistance to QACs is most often mediated by Qac efflux pumps. In this Final Thesis, the antimicrobial potential of commercial QACs, cetilpiridinium chloride and benzalkonium bromide, as well as their potential for developing resistance mediated by the Qac efflux pumps, was examined. Tests were performed on the bacterium Staphylococcus aureus ATCC 33591, where the minimum inhibitory concentrations (MIC) of these compounds were determined without and in the presence of the ATP-synthase inhibitor, carbonyl cyanide m-chlorophenyl hydrazone. The obtained results point to the conclusion that both commercial QACs compounds are substrates of Qac efflux pumps, which confirms published data on the increasing incidence of resistance to these compounds.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:939068
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-02-14 13:43:04