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undergraduate thesis
Bakteriocini, antimikrobni peptidi iz bakterija, kao novi lijekovi
2021. urn:nbn:hr:166:364078
Jerončić, Ana Josipa
University of Split
University of Split, Faculty of science
Department of Biology

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Jerončić, A. J. (2021). Bakteriocini, antimikrobni peptidi iz bakterija, kao novi lijekovi (Undergraduate thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:364078

Jerončić, Ana Josipa. "Bakteriocini, antimikrobni peptidi iz bakterija, kao novi lijekovi." Undergraduate thesis, University of Split, University of Split, Faculty of science, 2021. https://urn.nsk.hr/urn:nbn:hr:166:364078

Jerončić, Ana Josipa. "Bakteriocini, antimikrobni peptidi iz bakterija, kao novi lijekovi." Undergraduate thesis, University of Split, University of Split, Faculty of science, 2021. https://urn.nsk.hr/urn:nbn:hr:166:364078

Jerončić, A. J. (2021). 'Bakteriocini, antimikrobni peptidi iz bakterija, kao novi lijekovi', Undergraduate thesis, University of Split, University of Split, Faculty of science, accessed 23 May 2022, https://urn.nsk.hr/urn:nbn:hr:166:364078

Jerončić AJ. Bakteriocini, antimikrobni peptidi iz bakterija, kao novi lijekovi [Undergraduate thesis]. Split: University of Split, University of Split, Faculty of science; 2021 [cited 2022 May 23] Available at: https://urn.nsk.hr/urn:nbn:hr:166:364078

A. J. Jerončić, "Bakteriocini, antimikrobni peptidi iz bakterija, kao novi lijekovi", Undergraduate thesis, University of Split, University of Split, Faculty of science, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:166:364078

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Metadata
TitleBakteriocini, antimikrobni peptidi iz bakterija, kao novi lijekovi
Title (english)Bacteriocins, antimicrobial peptides from bacteria, as novel therapeutics
AuthorAna Josipa Jerončić
MentorIvica Šamanić (mentor)
MentorTomislav Rončević (pomoć pri izradi, neposredni voditelj)
Committee memberIvica Šamanić (predsjednik povjerenstva)
Committee memberAna Maravić (član povjerenstva)
Committee memberTomislav Rončević (član povjerenstva)
GranterUniversity of Split
University of Split, Faculty of science
(Department of Biology)
Split
Defense date and country2021-09-24, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U zadnjih nekoliko desetljeća bakterijska rezistencija naspram antibiotika je postala jedan od gorućih zdravstvenih problema diljem svijeta. Kao potencijalni odgovor danas se, među ostalim, razmatraju antimikrobni peptidi (AMP) - multifunkcionalne molekule s direktnom antimikrobnom aktivnosti i/ili imunomodulatornim djelovanjem. Jedna važna skupina ovih peptida su bakteriocini, ribosomski sintetizirani AMP-i iz bakterija. Ovi peptidi, koje sintetiziraju gram-pozitivne i gram-negativne bakterije osim antibakterijske, pokazuju i antivirusnu, te antitumorsku aktivnost. Unatoč velikom terapeutskom potencijalu, bakteriocini do danas nisu ušli u kliničku primjenu zbog nedostataka koji se povezuju s većinom poznatih AMP-a, a to su visoki troškovi proizvodnje, toksičnost naspram stanica domaćina i nestabilnost u fiziološkim uvjetima. Iz tog razloga, brojna istraživanja su fokusirana na modificiranje ovih peptida kako bi se dizajnirali i sintetizirali analozi s poboljšanim svojstvima.
Abstract (english)
In the last few decades, bacterial resistance to antibiotics has become one of the largest health concerns worldwide. As a potential answer to the growing concern, antimicrobial peptides (AMPs) are being investigated. These are multifunctional molecules with direct antimicrobial activity and/or immunomodulatory properties. An important group of these types of peptides are bacteriocins, ribosomally synthesized peptides from bacteria. These peptides, which can be synthesized by gram-positive and gram-negative bacteria, show not only antibacterial, but also antiviral and anticancer activity. Even though bacteriocins show promising therapeutic potential, they are yet to be adapted into clinical use due to their shortcomings, similar as the most other known AMPs, such as high costs of production, toxicity to the host cells and low stability in physiological conditions. For that reason, current researches are focused on modifying these peptides in order to design and synthesize analogues with improved properties.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:364078
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-10-12 12:01:16