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undergraduate thesis
Uloga ABC transportera u razvoju rezistentnih tumora
2020. urn:nbn:hr:166:595262
Radić, Matea
University of Split
Faculty of Science
Department of Chemistry

Cite this document

Radić, M. (2020). Uloga ABC transportera u razvoju rezistentnih tumora (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:595262

Radić, Matea. "Uloga ABC transportera u razvoju rezistentnih tumora." Undergraduate thesis, University of Split, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:166:595262

Radić, Matea. "Uloga ABC transportera u razvoju rezistentnih tumora." Undergraduate thesis, University of Split, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:166:595262

Radić, M. (2020). 'Uloga ABC transportera u razvoju rezistentnih tumora', Undergraduate thesis, University of Split, Faculty of Science, accessed 07 December 2024, https://urn.nsk.hr/urn:nbn:hr:166:595262

Radić M. Uloga ABC transportera u razvoju rezistentnih tumora [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2020 [cited 2024 December 07] Available at: https://urn.nsk.hr/urn:nbn:hr:166:595262

M. Radić, "Uloga ABC transportera u razvoju rezistentnih tumora", Undergraduate thesis, University of Split, Faculty of Science, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:166:595262

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Metadata
TitleUloga ABC transportera u razvoju rezistentnih tumora
Title (english)The role of ABC transporters in development of tumor resistance
AuthorMatea Radić
MentorMatilda Šprung (mentor)
Committee memberMatilda Šprung (predsjednik povjerenstva)
Committee memberStjepan Orhanović (član povjerenstva)
Committee memberDoris Crnčević (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Chemistry)
Split
Defense date and country2020-09-14, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
ABC transporteri su membranski proteini koji koriste energiju ATP-a za prijenos različitih molekula preko stanične membrane. Prisutni su kod svih organizama s određenim razlikama u načinu djelovanja. Istraživanjem molekularnih mehanizama kod malignih oboljenja, otkriveno je da pojedini ABC proteini imaju potencijalnu ulogu u razvoju rezistencije tumorskih stanica na lijekove. To su: P-glikoprotein, MRP1 i BCRP. Danas, sve veći broj ljudi obolijeva od malignih bolesti i liječenje često biva neuspješno. Jedan od razloga neuspješnog liječenja su upravo i ABC transporteri koji mogu utjecati na apsorpciju, distribuciju, metabolizam, ekskreciju i toksičnost lijeka. Smatra se da bi razvoj načina inhibicije njihovog djelovanja značilo prekretnicu u kliničkom liječenju malignih bolesti.
Abstract (english)
ABC transporters are membrane proteins that use the energy of ATP to transfer various molecules across the cell membrane. They are present in all organisms with certain differences in the mode of action. By investigating the molecular mechanisms in malignant diseases, it has been discovered that certain ABC proteins have a potential role in the development of drug resistance of tumor cells. These are: P-glycoprotein, MRP1 and BCRP. Today, an increasing number of people are suffering from malignant diseases and treatment is often unsuccessful. One of the reasons for unsuccessful treatment are ABC transporters, which can affect the absorption, distribution, metabolism, excretion and toxicity of the drug. It is a general opinion that the development their inhibitors would mean a turning point in the clinical treatment of malignant diseases.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:595262
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2021-01-11 14:09:40