prikaz prve stranice dokumenta Antimikrobna aktivnost kvaternih soli piridinijeva-4-aldoksima
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master's thesis
Antimikrobna aktivnost kvaternih soli piridinijeva-4-aldoksima
2019. urn:nbn:hr:166:074564
Maleš, Ivana
University of Split
Faculty of Science
Department of Biology

Cite this document

Maleš, I. (2019). Antimikrobna aktivnost kvaternih soli piridinijeva-4-aldoksima (Master's thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:074564

Maleš, Ivana. "Antimikrobna aktivnost kvaternih soli piridinijeva-4-aldoksima." Master's thesis, University of Split, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:074564

Maleš, Ivana. "Antimikrobna aktivnost kvaternih soli piridinijeva-4-aldoksima." Master's thesis, University of Split, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:074564

Maleš, I. (2019). 'Antimikrobna aktivnost kvaternih soli piridinijeva-4-aldoksima', Master's thesis, University of Split, Faculty of Science, accessed 07 December 2024, https://urn.nsk.hr/urn:nbn:hr:166:074564

Maleš I. Antimikrobna aktivnost kvaternih soli piridinijeva-4-aldoksima [Master's thesis]. Split: University of Split, Faculty of Science; 2019 [cited 2024 December 07] Available at: https://urn.nsk.hr/urn:nbn:hr:166:074564

I. Maleš, "Antimikrobna aktivnost kvaternih soli piridinijeva-4-aldoksima", Master's thesis, University of Split, Faculty of Science, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:166:074564

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Metadata
TitleAntimikrobna aktivnost kvaternih soli piridinijeva-4-aldoksima
Title (english)Antimicrobial activity of pyridinium-4-aldoxime quaternary salts
AuthorIvana Maleš
MentorAna Maravić (mentor)
MentorRenata Odžak (komentor)
Committee memberAna Maravić (predsjednik povjerenstva)
Committee memberRenata Odžak (član povjerenstva)
Committee memberIvica Šamanić (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Biology)
Split
Defense date and country2019-12-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Cilj ovog istraživanja je ispitivanje antimikrobne aktivnosti kvaternih soli piridinijeva-4-aldoksima. Za istraživanje je korišteno šest klinički značajnih sojeva bakterija uključujući Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis, Listeria monocytogenes, Streptococcus pneumoniae, E. coli, te dvije gljivice Candida albicans i Aspergillus niger. Minimalne inhibitorne koncentracije (MIK) i minimalne baktericidne koncentracije (MBK) sintetiziranih spojeva određene su metodom mikrodilucije. Ispitivani spojevi pokazuju veću učinkovitost na gljivice nego na bakterije. Najbolji antifungalni učinak pokazali su spojevi 3, 6 i 7 s vrijednostima \(MIK_{50}\) od 62,5 μg/mL i \(MIK_{90}\) 125 μg/mL na plijesan A. niger. Najbolju antibakterijsku aktivnost među ispitivanim spojevima pokazao je spoj 6 (\(Py-4-CF_{3}\)) gdje MIK i MBK tog spoja za bakterije E. faecalis, S. pyogenes i S. pneumoniae iznose 250 μg/mL. Ispitivanje inhibicije biofilma S. aureus ATCC 29213 najdjelotvornijeg spoja, spoj 6 (\(Py-4-CF_{3}\)), pokazalo je znatnu redukciju biofilma na subinhibitornim koncentracijama, poput 40% i 29,4% na četvrtini i osmini vrijednosti MIC-a.
Abstract (english)
The aim was to investigate the antimicrobial activity of pyridinium-4-aldoxime quaternary salts. Six clinically relevant strains of bacteria were used for the study including Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis, Listeria monocytogenes, Streptococcus pneumoniae, E. coli, and two fungi Candida albicans and Aspergillus niger. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of the synthesized compounds were determined by the microdilution method. The compounds tested showed greater efficacy on fungi than on bacteria. Compounds 3, 6 and 7 showed the best antifungal effect for A. niger with \(MIK_{50}\) values of 62,5 μg/mL and 125 μg/mL. The best antibacterial activity was shown by compound 6 (\(Py-4-CF_{3}\)) where the MIC and MBC of this compound for E. faecalis, S. pyogenes and S. pneumoniae bacteria were 250 μg/mL. Study of S. aureus ATCC 29213 biofilm inhibition by compound 6 (\(Py-4-CF_{3}\)) showed substantial reduction of biofilm formation at subinhibitory concentrations, including 40% and 29,4% at 1/4 and 1/8 of MIC values.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:074564
Study programmeTitle: Biology and Chemistry; specializations in: major in teaching
Course: major in teaching
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra edukacije biologije i kemije (magistar/magistra edukacije biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2019-12-18 14:03:40