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undergraduate thesis
Utjecaj metanolnih ekstrakata Allium x cornutum i Allium cepa na preživljavanje tumorskih HeLa stanica
2019. urn:nbn:hr:166:544782
Bajić, Danica
University of Split
Faculty of Science
Department of Biology

Cite this document

Bajić, D. (2019). Utjecaj metanolnih ekstrakata Allium x cornutum i Allium cepa na preživljavanje tumorskih HeLa stanica (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:544782

Bajić, Danica. "Utjecaj metanolnih ekstrakata Allium x cornutum i Allium cepa na preživljavanje tumorskih HeLa stanica." Undergraduate thesis, University of Split, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:544782

Bajić, Danica. "Utjecaj metanolnih ekstrakata Allium x cornutum i Allium cepa na preživljavanje tumorskih HeLa stanica." Undergraduate thesis, University of Split, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:544782

Bajić, D. (2019). 'Utjecaj metanolnih ekstrakata Allium x cornutum i Allium cepa na preživljavanje tumorskih HeLa stanica', Undergraduate thesis, University of Split, Faculty of Science, accessed 02 October 2024, https://urn.nsk.hr/urn:nbn:hr:166:544782

Bajić D. Utjecaj metanolnih ekstrakata Allium x cornutum i Allium cepa na preživljavanje tumorskih HeLa stanica [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2019 [cited 2024 October 02] Available at: https://urn.nsk.hr/urn:nbn:hr:166:544782

D. Bajić, "Utjecaj metanolnih ekstrakata Allium x cornutum i Allium cepa na preživljavanje tumorskih HeLa stanica", Undergraduate thesis, University of Split, Faculty of Science, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:166:544782

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Metadata
TitleUtjecaj metanolnih ekstrakata Allium x cornutum i Allium cepa na preživljavanje tumorskih HeLa stanica
Title (english)The effect of Allium x cornutum and Allium cepa methanolic extracts on survival of HeLa cancer cells
AuthorDanica Bajić
MentorŽeljana Fredotović (mentor)
Committee memberŽeljana Fredotović (predsjednik povjerenstva)
Committee memberElma Vuko (član povjerenstva)
Committee memberIvica Šamanić (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Biology)
Split
Defense date and country2019-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Biljke i biljni derivati potencijalni su izvori biološki aktivnih spojeva koji su sposobni ometati kancerogene procese. Ovoj skupini pripadaju i biljke roda Allium, bogate polifenolima i organosumpornim spojevima s antioksidativnim i antikancerogenim djelovanjem. Cilj rada bio je ispitati utjecaj metanolnih ekstrakata Allium × cornutum i A. cepa na preživljavanje tumorskih HeLa stanica. Stanice su tretirane ekstraktima (koncentracije 100 µg/ml) nakon čega im je određena vijabilnost, te provjerena morfologija i cjelovitost DNA molekule. Oba ekstrakta pokazala su inhibitorni učinak na rast i proliferaciju HeLa stanica. Uočena je promjena morfologije stanica, te fragmentacija DNA molekule nastale kao posljedica apoptoze. Potrebno je provesti ispitivanja na drugim staničnim linijama i in vivo modelnim organizmima kako bi se potvrdio antikancerogeni potencijal Allium esktrakata.
Abstract (english)
Plants and plant derivatives are potential sources of biologically active compounds that are capable of disrupting carcinogenic processes. This group also includes plants of the genus Allium, rich in polyphenols and organosulfur compounds with antioxidant and anticancer effects. The aim of the study was to explore the influence of methanolic extracts of Allium × cornutum and A. cepa on the survival of tumor HeLa cells. The cells were treated with extracts (concentrations of 100 µg/ml), after which their viability was determined, and the morphology and integrity of the DNA molecule. Both extracts showed an inhibitory effect on the growth and proliferation of HeLa cells. Changes in cell morphology and fragmentation of DNA molecules resulting from apoptosis have been observed. Studies on other cell lines and in vivo model organisms need to be performed to confirm the anticancer potential of Allium extracts.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:544782
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2019-11-06 08:23:36