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Preimplantacijska genetička dijagnostika
Ivana Kero (2019)
University of Split
University of Split, Faculty of science
Department of Biology
Cite this document

Kero, I. (2019). Preimplantacijska genetička dijagnostika (Undergraduate thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:692857

Kero, Ivana. "Preimplantacijska genetička dijagnostika." Undergraduate thesis, University of Split, University of Split, Faculty of science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:692857

Kero, Ivana. "Preimplantacijska genetička dijagnostika." Undergraduate thesis, University of Split, University of Split, Faculty of science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:692857

Kero, I. (2019). 'Preimplantacijska genetička dijagnostika', Undergraduate thesis, University of Split, University of Split, Faculty of science, accessed 04 April 2020, https://urn.nsk.hr/urn:nbn:hr:166:692857

Kero I. Preimplantacijska genetička dijagnostika [Undergraduate thesis]. Split: University of Split, University of Split, Faculty of science; 2019 [cited 2020 April 04] Available at: https://urn.nsk.hr/urn:nbn:hr:166:692857

I. Kero, "Preimplantacijska genetička dijagnostika", Undergraduate thesis, University of Split, University of Split, Faculty of science, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:166:692857

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Metadata
TitlePreimplantacijska genetička dijagnostika
Title (english)Preimplantation genetic diagnosis
AuthorIvana Kero
MentorŽeljana Fredotović (mentor)
Committee memberŽeljana Fredotović (predsjednik povjerenstva)
Committee memberAna Maravić (član povjerenstva)
Committee memberIvica Šamanić (član povjerenstva)
GranterUniversity of Split
University of Split, Faculty of science
(Department of Biology)
Split
Defense date and country2019-09-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Preimplantacijska genetička dijagnostika (PGD) je klinički dijagnostički postupak koji je razvijen za determinaciju genetički nasljednih bolesti u preimplantiranim embrijima. Uz primjenu PGD - a u potpomognutoj oplodnji (IVF), smanjio se broj spontanih pobačaja i značajno povećala stopa uspješnih trudnoća kod parova s rizikom od prenošenja bolesti na zametak. Raniji postupci su uključivali invazivnije metode biopsije stanica za testiranje, no uz današnji napredak, rezultati su vidljivi i uz biopsiju polarnog tijela ili trofektodermskih stanica. Prve tehnike PGD - a uključivale su polimeraznu lančanu reakciju (PCR) te fluorescentnu in situ hibridizaciju (FISH) koje su danas zamijenile novi molekularni alati poput DNA mikročipova i sekvenciranja sljedeće generacije (NGS). Nove metode pomogle su prevladati rizik i poboljšati ukupne analize preimplantacijske genetičke dijagnostike. Cilj ovog rada je dati bolji uvid u molekularne tehnike koje se koriste pri PGD - u i bolje razumijevanjepolja reproduktivne genetike.
Abstract (english)
Preimplantation genetic diagnosis (PGD) is a clinical diagnostic procedure developed for the determination of genetically inherited diseases in pre-implanted embryos. Introduction of PGD in in vitro fertilization caused the reduction of miscarriages and increasedthe rate of successfully carried pregnancies in couples with higher risk of transmitting a disease to their offspring. Early procedures included more invasive biopsy methods, but with great advancements, the results are visible with polar body biopsy or even trophectoderm cells. First PGD techniques included polymerase chain reaction (PCR) and fluorescent in situ hybridization (FISH), but today they are replaced with new molecular tools such as DNA array and next-generation sequencing. New methods have helped to overcome certain risks and to improve overall PGD analysis. Main aim of this thesis is to give a better insight into molecular techniques that are used in PGD as well as in the field of reproductive genetics.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:692857
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
Created on2019-10-11 08:19:59