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undergraduate thesis
Antimikrobni peptidi u morskim školjkašima - imunološki odgovor i biomedicinski potencijal
2018. urn:nbn:hr:166:498997
Ripić, Martin
University of Split
Faculty of Science
Department of Biology

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Ripić, M. (2018). Antimikrobni peptidi u morskim školjkašima - imunološki odgovor i biomedicinski potencijal (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:498997

Ripić, Martin. "Antimikrobni peptidi u morskim školjkašima - imunološki odgovor i biomedicinski potencijal." Undergraduate thesis, University of Split, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:166:498997

Ripić, Martin. "Antimikrobni peptidi u morskim školjkašima - imunološki odgovor i biomedicinski potencijal." Undergraduate thesis, University of Split, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:166:498997

Ripić, M. (2018). 'Antimikrobni peptidi u morskim školjkašima - imunološki odgovor i biomedicinski potencijal', Undergraduate thesis, University of Split, Faculty of Science, accessed 25 October 2024, https://urn.nsk.hr/urn:nbn:hr:166:498997

Ripić M. Antimikrobni peptidi u morskim školjkašima - imunološki odgovor i biomedicinski potencijal [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2018 [cited 2024 October 25] Available at: https://urn.nsk.hr/urn:nbn:hr:166:498997

M. Ripić, "Antimikrobni peptidi u morskim školjkašima - imunološki odgovor i biomedicinski potencijal", Undergraduate thesis, University of Split, Faculty of Science, Split, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:166:498997

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Metadata
TitleAntimikrobni peptidi u morskim školjkašima - imunološki odgovor i biomedicinski potencijal
Title (english)Antimicrobial peptides in marine bivalve - immune response and biomedical potential
AuthorMartin Ripić
MentorAna Maravić (mentor)
MentorTomislav Rončević (pomoć pri izradi, neposredni voditelj)
Committee memberAna Maravić (predsjednik povjerenstva)
Committee memberTomislav Rončević (član povjerenstva)
Committee memberSanja Puljas (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Biology)
Split
Defense date and country2018-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U zadnjih nekoliko godina, patogene bakterije su razvile rezistenciju na većinu poznatih klasa antibiotika, uključujući pojavu višestruko rezistentnih „superbakterija“. Javila se potreba za razvojem novih terapeutika, a kao potencijalni kandidati nameću se antimikrobni peptidi (AMP) koji čine sastavni dio urođenog imunološkog sustava svih živućih vrsta na Zemlji. Velika strukturalna različitost i multimodalni mehanizam djelovanja koji često uključuje narušavanje membranskog integriteta stanice, omogućuju im aktivnost širokog spektra naspram patogenih mikroorganizama. Proučavanje AMP-a iz morskih školjkaša je bitno iz evolucijske perspektive, ali i njihovog biomedicinskog potencijala u razvoju novih lijekova.Unatoč obećavajućim uspjesima, AMP još nisu zaživjeli svoj puni potencijal u medicini prvenstveno zbog skupih troškova proizvodnje, često visoke toksičnosti po stanice čovjeka i velike nestabilnosti u in vivo uvjetima.
Abstract (english)
In recent years, pathogenic bacteria have developed resistance to most of the antibiotic classes in use today, including emergence of multi-resistant „superbacteria“. Therefore, there is a need for a development of new therapeutics, and one of possible solutions are antimicrobial peptides (AMPs), endogenous antibiotics present in all living organisms. Their diverse structures and multimodal mode of action which often includes cell membrane disruption, enables them with broad-spectrum activity against pathogenic microorganisms. Studying AMPs identified from sea shellfish is important from evolutionarily point of view, and also due to their biomedical potential in the development of novel drugs. Despite promising success, AMPs have not yet reached their full potential in medicine, primarily due to expensive production costs, often high levels of toxicity towards human cells and high instability in in vivo conditions.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:498997
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-10-29 16:10:13