BPA je kemikalija koja se koristi u proizvodnji polikarbonatne plastike i epoksidnih smola. Njihova široka upotreba i sposobnost BPA da migrira iz njih uzrok su zašto je BPA toliko raširen i prisutan u okolišu. U ljudskom tijelu glavni metabolički put za eliminaciju BPA je glukouronizacija, dok je manje bitan put sulfatizacija. Većinu metabolita BPA koji nastaju uz citokrom P450 karakterizira jača estrogena aktivnost. Jedan metabolit MBP ima 1000 puta veću estrogenu aktivnost. BPA djeluje preko hormonskih receptora, G-protein spregnutog receptora i djelujući direktno na DNK. BPA je endokrini disruptor, štetno utječe na reprodukciju. Pronađena je veza s pojavom metaboličkih bolesti, ima ulogu u kancerogenezi. Ometa funkcioniranje gušterače i slabi imunitet.

Bisphenol A is a chemical used in the production of polycarbonate plastic and epoxy resin. Their widespread use and the ability of BPA to migrate is the reason why BPA is so common in our environment. In the human body, the main metabolic pathway for elimination of BPA is glucouronidation, while sulfatation is the less important. Most BPA metabolites formed at presence of cytochrome P450 have higher estrogenic activity. One metabolite, MBP has 1000 times greater estrogenic activity. BPA binds with hormone receptors, G-protein coupled receptors and acts on DNA directly. BPA is an endocrine disruptor, it adversely affects reproduction. It is linked with the occurrence of metabolic diseases, it has a role in cancerogenesis. BPA impairs function of pancreas and weakens immunity.