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undergraduate thesis
Azaspiracidi - struktura i biotransformacije
2024. urn:nbn:hr:166:635378
Pomper, Dina
University of Split
Faculty of Science

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Pomper, D. (2024). Azaspiracidi - struktura i biotransformacije (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:635378

Pomper, Dina. "Azaspiracidi - struktura i biotransformacije." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:635378

Pomper, Dina. "Azaspiracidi - struktura i biotransformacije." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:635378

Pomper, D. (2024). 'Azaspiracidi - struktura i biotransformacije', Undergraduate thesis, University of Split, Faculty of Science, accessed 16 October 2024, https://urn.nsk.hr/urn:nbn:hr:166:635378

Pomper D. Azaspiracidi - struktura i biotransformacije [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2024 [cited 2024 October 16] Available at: https://urn.nsk.hr/urn:nbn:hr:166:635378

D. Pomper, "Azaspiracidi - struktura i biotransformacije", Undergraduate thesis, University of Split, Faculty of Science, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:166:635378

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Metadata
TitleAzaspiracidi - struktura i biotransformacije
Title (english)Azaspiracids - structure and biotransformations
AuthorDina Pomper
MentorStjepan Orhanović (mentor)
Committee memberStjepan Orhanović (predsjednik povjerenstva)
Committee memberAndrea Paut (član povjerenstva)
Committee memberDoris Crnčević (član povjerenstva)
GranterUniversity of Split
Faculty of Science
Split
Defense date and country2024-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Azaspiracidi su morski toksini, koji se akumuliraju u školjkašima i drugim organizmima koji se hrane filtriranjem morske vode. Konzumacijom kontaminiranih morskih plodova dolazi do azaspiracidnog trovanja školjkašima, pri čemu se javljaju neugodni gastrointestinalni simptomi kao što su mučnina, povraćanje, proljev i grčevi u želudcu. Azaspiracide proizvode dinoflagelati Azadinium spinosum, Azadinium poporum, Azadinium dexteroporum i manje poznata vrsta Amphidoma languida. Struktura ovih toksina uključuje ciklički amin, jedinstveni spiro-sklop i karboksilnu skupinu. Do otkrića dinoflagelata koji proizvode azaspiracide, analozi ovih toksina bili su izolirani isključivo iz školjaka. Nakon identifikacije vrste A. spinosum, opisano je 26 novih analoga algalnog podrijetla. Azaspiracidi akumulirani u školjkama podliježu različitim biotransformacijama, koje rezultiraju stvaranjem brojnih analoga azaspiracida. Neke biotransformacije poput metilacije i epimerizacije povećavaju toksičnost azaspiracida, dok ostale uglavnom stvaraju manje toksične analoge.
Abstract (english)
Azaspiracids are marine toxins that accumulate in shellfish and other filter-feeding marine organisms. Consuming contaminated seafood leads to azaspiracid shellfish poisoning, which can cause unpleasant gastrointestinal symptoms such as nausea, vomiting, diarrhea and stomach cramps. Azaspiracids are produced by the dinoflagellates Azadinium spinosum, Azadinium poporum, Azadinium dexteroporum and the lesser-known species Amphidoma languida. The structure of these toxins includes a cyclic amine, a unique spiro assembly and a carboxyl group. Until the discovery of azaspiracid-producing dinoflagellates, analogues of these toxins were isolated exclusively from shellfish. After the identification of the species A. spinosum, 26 new analogues of algal origin were described. Azaspiracids accumulated in shellfish undergo various biotransformations, which result in the formation of different azaspiracid analogues. Some biotransformations, such as methylation and epimerization, increase the toxicity of azaspiracids, while the others mainly generate less toxic analogues.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:635378
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-16 11:49:18