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undergraduate thesis
Uloga retinoida u zdravlju kože: mehanizmi, dobrobiti i budući smjerovi
2024. urn:nbn:hr:166:387306
Mrše, Lucia
University of Split
Faculty of Science

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Mrše, L. (2024). Uloga retinoida u zdravlju kože: mehanizmi, dobrobiti i budući smjerovi (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:387306

Mrše, Lucia. "Uloga retinoida u zdravlju kože: mehanizmi, dobrobiti i budući smjerovi." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:387306

Mrše, Lucia. "Uloga retinoida u zdravlju kože: mehanizmi, dobrobiti i budući smjerovi." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:387306

Mrše, L. (2024). 'Uloga retinoida u zdravlju kože: mehanizmi, dobrobiti i budući smjerovi', Undergraduate thesis, University of Split, Faculty of Science, accessed 28 November 2024, https://urn.nsk.hr/urn:nbn:hr:166:387306

Mrše L. Uloga retinoida u zdravlju kože: mehanizmi, dobrobiti i budući smjerovi [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2024 [cited 2024 November 28] Available at: https://urn.nsk.hr/urn:nbn:hr:166:387306

L. Mrše, "Uloga retinoida u zdravlju kože: mehanizmi, dobrobiti i budući smjerovi", Undergraduate thesis, University of Split, Faculty of Science, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:166:387306

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Metadata
TitleUloga retinoida u zdravlju kože: mehanizmi, dobrobiti i budući smjerovi
Title (english)The role of retinoids in skin health: mechanisms, benefits and future directions
AuthorLucia Mrše
MentorViljemka Bučević Popović (mentor)
Committee memberViljemka Bučević Popović (predsjednik povjerenstva)
Committee memberStjepan Orhanović (član povjerenstva)
Committee memberMatilda Šprung (član povjerenstva)
GranterUniversity of Split
Faculty of Science
Split
Defense date and country2024-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Retinoidi, sintetski ili prirodni derivati vitamina A, koriste se u tretiranju promijenjenog izgleda kože, koji nastaje zbog intrinzičnog i ekstrinzičnog starenje ili različitih kožnih oboljenja poput akni. Kako bi došli do ciljnih stanica, moraju proći pretvorbe iz jednog oblika u drugi, a zatim vezani za stanične retinoid-vezujuće proteine (CRABP) doći do nuklearnih receptora. Retinol, jedan od derivata vitamina A, zbog svoje lipofilne prirode prolazi do epidermisa i dermisa. Povećava debljinu epidermisa, proliferaciju keratinocita, broj dermalnih proteina izvanstaničnog matriksa i broj krvnih žila te tako poboljšava nepravilan i oštećen izgled kože. Također, retinoidi koji su se pokazali učinkovitima za liječenje akni su trifaroten i oralni izotretinoin. Ponekad primjena retinoida, osim pozitivnih utjecaja, uzrokuje nuspojave. Neke od njih su: svrbež, peckanje, eritem, suhoća i ljuskanje. Kako bi izbjegli negativne posljedice korištenja retinoida znanstvenici su u potrazi za novim unaprijeđenim formulacijama retinoida kao što su nanočestice, liposomi, mikroemulzije i mikrospužve.
Abstract (english)
Retinoids, synthetic or natural derivatives of vitamin A, are used to address the changed appearance of the skin, which occurs due to intrinsic and extrinsic aging or various skin conditions such as acne. To reach the target cells, they must undergo conversion from one form to another, and then bound to cellular retinoid binding protein (CRABP) reach nuclear receptors. Retinol, one of the derivatives of vitamin A, penetrates the epidermis and dermis due to its lipophilic nature. It increases the thickness of the epidermis, the proliferation of keratinocytes, the number of dermal extracellular matrix proteins and the number of blood vessels, thus improving the irregular and damaged appearance of the skin. Also, retinoids that have shown a positive impact on the appearance of skin with acne are trifarotene and oral isotretinoin. Sometimes the use of retinoids, in addition to positive effects, causes side effects. Some of them are itching, burning, erythema, dryness and scaling. To avoid the negative consequences of using retinoids, scientists are looking for new, more stable formulations of retinoids such as nanoparticles, liposomes, microemulsions and microsponges.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:387306
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2024-09-26 11:43:36