prikaz prve stranice dokumenta Morphological characterization of spiral ganglion neurons grown in the pulsating electromagnetic field
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master's thesis
Morphological characterization of spiral ganglion neurons grown in the pulsating electromagnetic field
2022. urn:nbn:hr:166:100785
Borić, Tina
University of Split
Faculty of Science
Department of Physics

Cite this document

Borić, T. (2022). Morphological characterization of spiral ganglion neurons grown in the pulsating electromagnetic field (Master's thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:100785

Borić, Tina. "Morphological characterization of spiral ganglion neurons grown in the pulsating electromagnetic field." Master's thesis, University of Split, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:166:100785

Borić, Tina. "Morphological characterization of spiral ganglion neurons grown in the pulsating electromagnetic field." Master's thesis, University of Split, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:166:100785

Borić, T. (2022). 'Morphological characterization of spiral ganglion neurons grown in the pulsating electromagnetic field', Master's thesis, University of Split, Faculty of Science, accessed 28 October 2024, https://urn.nsk.hr/urn:nbn:hr:166:100785

Borić T. Morphological characterization of spiral ganglion neurons grown in the pulsating electromagnetic field [Master's thesis]. Split: University of Split, Faculty of Science; 2022 [cited 2024 October 28] Available at: https://urn.nsk.hr/urn:nbn:hr:166:100785

T. Borić, "Morphological characterization of spiral ganglion neurons grown in the pulsating electromagnetic field", Master's thesis, University of Split, Faculty of Science, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:166:100785

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Metadata
TitleMorphological characterization of spiral ganglion neurons grown in the pulsating electromagnetic field
Title (croatian)Morfološka karakterizacija neurona spiralnog ganglija uzgojenih u pulsirajućem elektromagnetskom polju
AuthorTina Borić
MentorDamir Kovačić (mentor)
Committee memberDamir Kovačić (predsjednik povjerenstva)
Committee memberLarisa Zoranić (član povjerenstva)
Committee memberIvana Weber (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Physics)
Split
Defense date and country2022-12-02, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Biophysics and Medical Physics
Abstract
Spiral ganglion neurons (SGNs), located in the modiolus of the cochlea, transmit auditory signals from mechanosensory hair cells to the cochlear nucleus in the brain stem. Damage of sensitive hair cells, the most common cause of hearing loss, typically leads to the degeneration of SGNs. A cochlear implant (CI), as the most successful neuroprosthetic clinical intervention, allows patients with hearing loss to bypass damaged hair cells by direct electrical stimulation of SGNs. However, one of the main limitations of cochlear implants is the neuroanatomical gap between electrodes and nerve fibers. Finding ways to influence neurite growth direction to reduce the anatomical gap would highly improve a cochlear implant's spatial and temporal resolution. This thesis investigated the effect of substrate type and electromagnetic field (EMF) on the morphology and orientation of SGNS. We conclude that the EMF may reduce the soma radii of SGNs while the micro pillared substrates have the potential to enlarge them. In addition, we found a significant influence of EMF and substrate type on the orientation of SGNs.
Abstract (croatian)
Neuroni spiralnog ganglija (NSG), smješteni u modiolusu pužnice, prenose slušne signale od slušnih stanica dlačica do kohlearne jezgre u moždanom deblu. Oštećenje ili gubitak neurona spiralnih ganglija i slušnih stanica primarni je uzrok gubitka sluha. Kohlearna implantacija jedan je od najuspješnijih načina obnavljanja osjeta sluha kod ljudi sa slušnim oštećenjem. Jedno od glavnih ograničenja kohlearnog implantata je postojanje anatomske praznine između elektroda i živčanih vlakana. Otkriće metoda kojima bi se moglo utjecati na smjer rasta neurita, u svrhu smanjivanja te anatomske praznine, značajno bi poboljšalo prostornu i vremensku rezoluciju kohlearnog implanta. Cilj ovog rada bio je ispitati mogu li na morfologiju i orijentaciju neurona spiralnog ganglija utjecati vrsta podloge i elektromagnetsko polje. Utvrđeno je da prisutnost elektromagnetskog polja smanjuje radijuse tijela neurona spiralnog ganglija, dok ih supstrati s mikropilarima povećavaju. Osim toga, pokazalo se da vrsta podloge i elektromagnetsko polje značajno utječu na orijentaciju neurona spiralnog ganglija. Dobiveni nalazi poticaj su za daljnja istraživanja ovog područja.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:166:100785
Study programmeTitle: Physics; specializations in: major in teaching, major in Astrophysics, major in Biophysics, major in Enviromental physics, major in Computational physics, major in Astrophysics and physics of elemental particles
Course: major in Biophysics
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra fizike (magistar/magistra fizike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2023-02-20 13:49:32