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undergraduate thesis
Genomski utisak: utjecaj roditelja na genom
2020. urn:nbn:hr:166:586125
Budimir, Tina
University of Split
Faculty of Science
Department of Biology

Cite this document

Budimir, T. (2020). Genomski utisak: utjecaj roditelja na genom (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:586125

Budimir, Tina. "Genomski utisak: utjecaj roditelja na genom." Undergraduate thesis, University of Split, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:166:586125

Budimir, Tina. "Genomski utisak: utjecaj roditelja na genom." Undergraduate thesis, University of Split, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:166:586125

Budimir, T. (2020). 'Genomski utisak: utjecaj roditelja na genom', Undergraduate thesis, University of Split, Faculty of Science, accessed 19 November 2024, https://urn.nsk.hr/urn:nbn:hr:166:586125

Budimir T. Genomski utisak: utjecaj roditelja na genom [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2020 [cited 2024 November 19] Available at: https://urn.nsk.hr/urn:nbn:hr:166:586125

T. Budimir, "Genomski utisak: utjecaj roditelja na genom", Undergraduate thesis, University of Split, Faculty of Science, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:166:586125

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Metadata
TitleGenomski utisak: utjecaj roditelja na genom
Title (english)Genomic imprinting: parental influence on the genome
AuthorTina Budimir
MentorŽeljana Fredotović (mentor)
Committee memberŽeljana Fredotović (predsjednik povjerenstva)
Committee memberElma Vuko (član povjerenstva)
Committee memberNives Kević (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Biology)
Split
Defense date and country2020-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Genomski utisak je epigenetski fenomen u kojem aktivnost gena ovisi o roditeljskom podrijetlu. Za razliku od Mendelovog nasljeđivanja gdje oba alela jednako doprinose fenotipu jedinke, utisnuti gen eksprimiran je samo s jednog roditeljskog alela, dok je alel naslijeđen od drugog roditelja utišan (inaktivan). Genomski utisak svoj trag ostavlja tijekom gametogeneze i ranog embrionalnog razvoja. Ovaj rad opisuje tri najznačajnija molekularna mehanizma u pozadini genomskog utiska: metilacija DNK, modifikacije histona i nekodirajuće RNK. Tijekom ranih istraživanja u području epigenetike, otkrivena su dva rijetka genetička poremećaja koja se dovode u direktnu vezu s genomskim utiskom, Prader-Willi i Angelmanov sindrom.
Abstract (english)
Genomic imprinting is an epigenetic phenomenon in which gene activity depends on parental origin. Unlike inheritance based on Mendel's laws where both alleles equally contribute to the phenotype of an individual, the imprinted gene is expressed only from one parental allele, while the allele inherited from the other parent is silenced (inactive). The genomic imprinting leaves its mark during gametogenesis and through the early embryonic development. In this thesis, we will discuss the three most important molecular mechanisms of genomic imprinting: DNA methylation, histone modification and noncoding RNA. During the first research in the field of epigenetics, two rare genetic disorders directly related to genomic imprinting were discovered, Prader-Willi and Angelman syndrome.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:586125
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to authenticated users
Terms of useLicence In copyright icon
Created on2021-01-15 11:25:53